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LGG

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Atg8/LC3 (1) Autophagy (1) CD28 (1) CGRP Receptor (1) Interleukin Related (1) PCSK9 (1) TNF Receptor (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Inflammation/Immunology (3) Neurological Disease (1)

Inhibitors & Agonists

Inhibitory Antibodies

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P9975

Theralizumab TGN1412; TAB08	CD28	Inflammation/Immunology
Theralizumab (TGN1412) is a humanized lgG4 superagonistic anti-CD28 monoclonal antibody that directly stimulates T cells. Theralizumab can cause cytokine release syndrome (CRS). Theralizumab can be used for the research of rheumatoid arthritis .

HY-P99019

Fremanezumab 2 Publications Verification TEV-48125; LBR-101; PF-04427429; RN-307	CGRP Receptor	Neurological Disease Inflammation/Immunology
Fremanezumab (TEV-48125) is a humanized lgG2 monoclonal antibody that selectively and potently binds to calcitonin gene related peptide (CGRp) (IC₅₀ values = 7.943 nM). Fremanezumab binds to mouse CGRP with an IC₅₀ value of 19.6 nM. Fremanezumab counteracts anti-inflammatory effects of CGRP in vitro, including CGRP-mediated inhibition of LPS (HY-D1056)-induced microglial activation. Fremanezumab selectively inhibits the activation of Aδ meningeal nociceptors by cortical spreading depression (CSD) in rats. Fremanezumab can be used for the study of inflammation and chronic migraine .

HY-P99552

Tafolecimab IBI-306	PCSK9	Cardiovascular Disease
Tafolecimab (IBI-306) is a human lgG2 monoclonal antibody that specifically binds PCSK-9 and reduces LDL-C levels by inhibiting PCSK-9-mediated endocytosis of the LDL receptor, which in turn enhances clearance of LDL-C and leads to a reduction in LDL-C levels. Tafolecimab may be used in studies of hypercholesterolaemia .

HY-121546

ALLO-1	Atg8/LC3 Autophagy	Cancer
ALLO-1, an autophagy receptor, is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 through its LC3-interacting region (LIR) motif .

HY-P991120

Balertatug PF-08046040; SGN-CD70	TNF Receptor	Cancer
Balertatug is a human IgG1K antibody targeting CD70. The corresponding isotype control is: Human lgG1 kappa, lsotype Control (HY-P99001) .

HY-P991119

Balekafusp alfa	Interleukin Related	Cancer
Balekafusp alfa is an IgG1K human antibody against IL-2 with anti-tumor activity. The corresponding isotype control is: Human lgG1 kappa, lsotype Control (HY-P99001) .

Cat. No.	Product Name	Target	Research Area	Image

HY-P9975

Theralizumab TGN1412; TAB08	CD28	Inflammation/Immunology
Theralizumab (TGN1412) is a humanized lgG4 superagonistic anti-CD28 monoclonal antibody that directly stimulates T cells. Theralizumab can cause cytokine release syndrome (CRS). Theralizumab can be used for the research of rheumatoid arthritis .

HY-P99019

Fremanezumab 2 Publications Verification TEV-48125; LBR-101; PF-04427429; RN-307	CGRP Receptor	Neurological Disease Inflammation/Immunology
Fremanezumab (TEV-48125) is a humanized lgG2 monoclonal antibody that selectively and potently binds to calcitonin gene related peptide (CGRp) (IC₅₀ values = 7.943 nM). Fremanezumab binds to mouse CGRP with an IC₅₀ value of 19.6 nM. Fremanezumab counteracts anti-inflammatory effects of CGRP in vitro, including CGRP-mediated inhibition of LPS (HY-D1056)-induced microglial activation. Fremanezumab selectively inhibits the activation of Aδ meningeal nociceptors by cortical spreading depression (CSD) in rats. Fremanezumab can be used for the study of inflammation and chronic migraine .

HY-P99986

*Mouse lgG2a (D265A) kappa, Isotype Control*	Inhibitory Antibodies	Inflammation/Immunology
Mouse lgG2a (D265A) kappa, Isotype Control, a mouse monoclonal antibody, is an isotype control for mouse lgG2a (D265A) antibody.

HY-P99552

Tafolecimab IBI-306	PCSK9	Cardiovascular Disease
Tafolecimab (IBI-306) is a human lgG2 monoclonal antibody that specifically binds PCSK-9 and reduces LDL-C levels by inhibiting PCSK-9-mediated endocytosis of the LDL receptor, which in turn enhances clearance of LDL-C and leads to a reduction in LDL-C levels. Tafolecimab may be used in studies of hypercholesterolaemia .

HY-P991120

Balertatug PF-08046040; SGN-CD70	TNF Receptor	Cancer
Balertatug is a human IgG1K antibody targeting CD70. The corresponding isotype control is: Human lgG1 kappa, lsotype Control (HY-P99001) .

HY-P991119

Balekafusp alfa	Interleukin Related	Cancer
Balekafusp alfa is an IgG1K human antibody against IL-2 with anti-tumor activity. The corresponding isotype control is: Human lgG1 kappa, lsotype Control (HY-P99001) .

HY-P991131

Daretabart	Inhibitory Antibodies	Cancer
Daretabart is a humanized IgG1K antibody targeting GD2, which can be used for anti-tumor research. The corresponding isotype control is: Human lgG1 kappa, lsotype Control (HY-P99001) .

Host:	Rat (1) Goat (3)
Reactivity:	Mouse (3) Rabbit (2)
Application:	IHC-P (3) mIHC (2) IHC-F (2) WB (1) ELISA (1)
Conjugation:	Polymer HRP (1) HRP (2)
Clonality:	Polyclonal (3) Monoclonal (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P87497

	*HRP-conjugated Anti-Mouse lgG* for IP** 1 Publications Verification	WB, ELISA	Mouse
	HRP-conjugated Anti-Mouse lgG is a conformation-specific secondary antibody that binds exclusively to native, non-denatured IgG and does not recognize denatured IgG. Conformation-specific secondary antibodies target spatial epitopes. When antibodies are denatured by high temperatures, they lose their native conformation and are no longer recognized by such antibodies—neither the heavy chain nor the light chain is detected. This effectively avoids interference from the heavy chain (55 kDa) and light chain (25 kDa) in immunoprecipitation (IP) experiments.

HY-P89365

	*Polymer HRP-conjugated Goat Anti-Mouse lgG(H&L) (Ready to use)*	IHC-P, IHC-F, mIHC	Mouse
	Polymer HRP-conjugated Goat Anti-Mouse lgG(H&L) (Ready to use) is a Polymer HRP-conjugated and Goat origined Mouse polyclonal antibody, targeting to mouse IgG H&L.

HY-P89366

	*Polymer HRP-conjugated Goat Anti-Rabbit lgG(H&L) (Ready to use)*	IHC-P, IHC-F, mIHC	Rabbit
	Polymer HRP-conjugated Goat Anti-Rabbit lgG(H&L) (Ready to use) is a Polymer HRP-conjugated and Goat origined Rabbit polyclonal antibody, targeting to rabbit IgG H&L.

HY-P83652

	*Polymer HRP-conjugated Goat Anti-Mouse/Rabbit lgG(H&L) (Ready to use)*	IHC-P	Mouse, Rabbit
	Polymer HRP-conjugated Goat Anti-Mouse/Rabbit lgG(H&L) is a universal (primary antibody host), ready-to-use, HRP-conjugated goat-derived antibody for both mouse and rabbit. In conventional immunohistochemical staining, it binds to the primary antibody to label the target.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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