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Results for "

Mcl-1S

" in MedChemExpress (MCE) Product Catalog:

3

Inhibitors & Agonists

2

Antibodies

1

Oligonucleotides

Cat. No. 상품명 Target 연구분야 Chemical Structure
  • HY-158783
    SACLAC

    		Ceramidase Bcl-2 Family LPL Receptor Apoptosis Neurological Disease
    SACLAC, a Ceramide analog, is a potent and covalent acid ceramidase (ASAH1; AC) inhibitor with a Ki of 97.1 nM. SACLAC effectively blocks AC activity and induces a decrease in sphingosine 1-phosphate (S1P) and total ceramide levels. SACLAC reduces the levels of splicing factor SF3B1 and alternative Mcl-1 mRNA splicing, increases pro-apoptotic Mcl-1S levels to induce apoptosis in acute myeloid leukemia (AML) cells. SACLAC reduces the leukemic burden in human AML xenograft mouse models [1] .
    SACLAC
  • HY-RS08230
    MCL1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Bcl-2 Family Others

    MCL1 Human Pre-designed siRNA Set A contains three designed siRNAs for MCL1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    MCL1 Human Pre-designed siRNA Set A
    MCL1 Human Pre-designed siRNA Set A
  • HY-15867
    Meayamycin B

    (+)-Meayamycin B

    		 SF3B1 Bcl-2 Family Apoptosis Cancer
    Meayamycin B ((+)-Meayamycin B) is a potent SF3B1 inhibitor. Meayamycin B upregulates the proapoptotic Mcl-1S and downregulates Mcl-1L at the pre-mRNA splicing level. Meayamycin B does not regulate the alternative splicing of Bcl-x. Meayamycin B and ABT-737 (HY-50907) synergistically causes Apoptosis. Meayamycin B exhibits anticancer activity against non-small cell lung cancer [1].
    Meayamycin B

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