NGFR

By Targets:	Apoptosis (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-111163

NSC49652	Apoptosis	Cancer
NSC49652 is a reversible, orally active p75 neurotrophin receptor (p75 ^NTR, also known as NGFR, TNFRSF16, and CD271) agonist. NSC49652 targets the transmembrane domain of p75 ^NTR. NSC49652 induces apoptosis and affects the viability of melanoma cells .

HY-RS09278

NGFR Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NGFR Human Pre-designed siRNA Set A contains three designed siRNAs for NGFR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NGFR Human Pre-designed siRNA Set A NGFR Human Pre-designed siRNA Set A

Cat. No.	Product Name

HY-L016

Protein Tyrosine Kinase Compound Library	1064 compounds
Protein tyrosine kinases (PTKs) are key signaling molecules and important drug targets. Two classes of PTKs are present in cells: the transmembrane receptor PTKs (RTKs) and the nonreceptor PTKs. The RTK family includes the receptors for insulin and for many growth factors, such as EGFR, FGFR, PDGFR, VEGFR, and NGFR. RTKs are transmembrane glycoproteins that are activated by the binding of their ligands, and they transduce the extracellular signal to the cytoplasm by phosphorylating tyrosine residues on the receptors themselves (autophosphorylation) and on downstream signaling proteins. Their principal functions of PTKs involve the regulation of multicellular aspects of the organism. Cell to cell signals concerning growth, differentiation, adhesion, motility, and death are frequently transmitted through tyrosine kinases. In humans, tyrosine kinases have been demonstrated to play significant roles in the development of many disease states, including diabetes and cancers. MCE designs a unique collection of 1064 compounds that act as a useful tool for PTKs-related drug screening and disease research.

Protein Tyrosine Kinase Compound Library

1064 compounds

Protein tyrosine kinases (PTKs) are key signaling molecules and important drug targets. Two classes of PTKs are present in cells: the transmembrane receptor PTKs (RTKs) and the nonreceptor PTKs. The RTK family includes the receptors for insulin and for many growth factors, such as EGFR, FGFR, PDGFR, VEGFR, and NGFR. RTKs are transmembrane glycoproteins that are activated by the binding of their ligands, and they transduce the extracellular signal to the cytoplasm by phosphorylating tyrosine residues on the receptors themselves (autophosphorylation) and on downstream signaling proteins. Their principal functions of PTKs involve the regulation of multicellular aspects of the organism. Cell to cell signals concerning growth, differentiation, adhesion, motility, and death are frequently transmitted through tyrosine kinases. In humans, tyrosine kinases have been demonstrated to play significant roles in the development of many disease states, including diabetes and cancers.

MCE designs a unique collection of 1064 compounds that act as a useful tool for PTKs-related drug screening and disease research.

Recombinant Proteins Recommended:

Nerve Growth Factor Receptor (NGFR)

Species:	Human (3) Mouse (2) Rabbit (2)
Tag:	His (3) Tag Free (1) Avi (1) Fc (3)
Source:	HEK293 (7)

Cat. No.	Compare	Product Name	Species	Source

HY-P74699

	NGFR Protein, Rabbit (HEK293, His) NGFR; Gp80-LNGFR; p75 ICD; CD271; TNFRSF16	Rabbit	HEK293
	Nerve Growth Factor Receptor (NGFR) also known as CD271, p75NTR, TNFRSF16, is a transmembrane low-affinity receptor for the neurotrophin family. NGFR has no intrinsic tyrosine kinase activity. NGFR can act as a tumour suppressor, negatively regulating cell growth and proliferation. NGF-NGFR cascade activates NF-κB, leading to inhibition of apoptosis, increases survival of schwannoma, and breast cancer cells. NGFR Protein, Human (HEK293, Fc) is a recombinant protein with a C-Terminal Fc label, It consists of 250 amino acids (M1-N250) and is produced in HEK293 cells. NGFR Protein, Rabbit (HEK293, His) is a recombinant protein with a C-Terminal His label, It consists of 242 amino acids (M1-D242) and is produced in HEK293 cells.

HY-P77100

	NGFR Protein, Mouse (HEK293, Fc) NGFR; Gp80-LNGFR; p75 ICD; CD271; TNFRSF16	Mouse	HEK293
	Nerve Growth Factor Receptor (NGFR) also known as CD271, p75NTR, TNFRSF16, is a transmembrane low-affinity receptor for the neurotrophin family. NGFR has no intrinsic tyrosine kinase activity. NGFR can act as a tumour suppressor, negatively regulating cell growth and proliferation. NGF-NGFR cascade activates NF-κB, leading to inhibition of apoptosis, increases survival of schwannoma, and breast cancer cells. NGFR Protein, Mouse (HEK293, Fc) is a recombinant protein with a C-Terminal Fc label, It consists of 243 amino acids (M1-N243) and is produced in HEK293 cells.

HY-P73318

	NGFR Protein, Human (HEK293, Fc) NGFR; Gp80-LNGFR; p75 ICD; CD271; TNFRSF16	Human	HEK293
	Nerve Growth Factor Receptor (NGFR) also known as CD271, p75NTR, TNFRSF16, is a transmembrane low-affinity receptor for the neurotrophin family. NGFR has no intrinsic tyrosine kinase activity. NGFR can act as a tumour suppressor, negatively regulating cell growth and proliferation. NGF-NGFR cascade activates NF-κB, leading to inhibition of apoptosis, increases survival of schwannoma, and breast cancer cells. NGFR Protein, Human (HEK293, Fc) is a recombinant protein with a C-Terminal Fc label, It consists of 250 amino acids (M1-N250) and is produced in HEK293 cells.

HY-P74700

	NGFR Protein, Rabbit (HEK293, hFc) NGFR; Gp80-LNGFR; p75 ICD; CD271; TNFRSF16	Rabbit	HEK293
	Nerve Growth Factor Receptor (NGFR) also known as CD271, p75NTR, TNFRSF16, is a transmembrane low-affinity receptor for the neurotrophin family. NGFR has no intrinsic tyrosine kinase activity. NGFR can act as a tumour suppressor, negatively regulating cell growth and proliferation. NGF-NGFR cascade activates NF-κB, leading to inhibition of apoptosis, increases survival of schwannoma, and breast cancer cells. NGFR Protein, Rabbit (HEK293, hFc) is a recombinant protein with a C-Terminal Fc label, It consists of 242 amino acids (M1-D242) and is produced in HEK293 cells.

HY-P77101

	NGFR Protein, Mouse (HEK293, His) NGFR; Gp80-LNGFR; p75 ICD; CD271; TNFRSF16	Mouse	HEK293
	Nerve Growth Factor Receptor (NGFR) also known as CD271, p75NTR, TNFRSF16, is a transmembrane low-affinity receptor for the neurotrophin family. NGFR has no intrinsic tyrosine kinase activity. NGFR can act as a tumour suppressor, negatively regulating cell growth and proliferation. NGF-NGFR cascade activates NF-κB, leading to inhibition of apoptosis, increases survival of schwannoma, and breast cancer cells. NGFR Protein, Mouse (HEK293, His) is a recombinant protein with a C-Terminal His label, It consists of 243 amino acids (M1-N243) and is produced in HEK293 cells.

HY-P7271

	NGFR Protein, Human (HEK293) rHuNGFR; Gp80-LNGFR; p75 ICD; CD271; TNFRSF16	Human	HEK293
	Nerve Growth Factor Receptor (NGFR) also known as CD271, p75NTR, TNFRSF16, is a transmembrane low-affinity receptor for the neurotrophin family. NGFR has no intrinsic tyrosine kinase activity. NGFR can act as a tumour suppressor, negatively regulating cell growth and proliferation. NGF-NGFR cascade activates NF-κB, leading to inhibition of apoptosis, increases survival of schwannoma, and breast cancer cells. NGFR Protein, Human (HEK293) is a recombinant protein consisting of 222 amino acids (K29-N250) and is produced in HEK293 cells.

HY-P700613

	NGFR Protein, Human (HEK293, His-Avi) rHuNGFR; Gp80-LNGFR; p75 ICD; CD271; TNFRSF16	Human	HEK293
	The NGFR protein is a low-affinity receptor that binds nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NTF3), and neurotrophin-4 (NTF4). NGFR cooperates with SORCS2 to form a high-affinity heterodimeric receptor for NGF, BDNF, and NTF3 precursor forms, but has lower affinity for mature NGF and BDNF. NGFR Protein, Human (HEK293, His-Avi) is the recombinant human-derived NGFR protein, expressed by HEK293 , with N-Avi, N-6*His labeled tag. The total length of NGFR Protein, Human (HEK293, His-Avi) is 399 a.a., with molecular weight of 46.54 kDa.


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Cat. No.	Product Name	Application	Reactivity

HY-P81500

p75 NGF Receptor Antibody (YA1245) NGFR; TNFRSF16; Tumor necrosis factor receptor superfamily member 16; Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD; CD antigen CD271	IHC-P	Human

HY-P83029

NGFR Antibody (YA2774) NGFR; TNFRSF16; Tumor necrosis factor receptor superfamily member 16; Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD; CD antigen CD271	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat

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