NGFR Protein, Human (Biotinylated, HEK293, His-Avi)

The NGFR protein is a low-affinity receptor that binds nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NTF3), and neurotrophin-4 (NTF4). NGFR cooperates with SORCS2 to form a high-affinity heterodimeric receptor for NGF, BDNF, and NTF3 precursor forms, but has lower affinity for mature NGF and BDNF. NGFR Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived NGFR protein, expressed by HEK293 , with N-Avi, N-6*His labeled tag.

NGFR (Low affinity nerve growth factor receptor), functioning as a low-affinity receptor, exhibits the capability to bind to nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NTF3), and neurotrophin-4 (NTF4). In partnership with SORCS2, NGFR forms a heterodimeric receptor with a high affinity for precursor forms of NGF, BDNF, and NTF3, whereas its affinity for mature NGF and BDNF is considerably lower. Playing a crucial role in the differentiation and survival of specific neuronal populations during development, NGFR can mediate both cell survival and cell death in neural cells. Additionally, NGFR contributes to the regulation of insulin-dependent glucose uptake by influencing the translocation of glucose transporter 4 (GLUT4) to the cell surface in adipocytes and skeletal muscle cells in response to insulin, possibly through the regulation of RAB31 activity. It is essential for the circadian oscillation of clock genes in the brain's suprachiasmatic nucleus and the genes involved in glucose and lipid metabolism in the liver. The NGFR receptor forms homodimers through disulfide linkage and heterodimers with SORCS2. Interactions with various proteins, such as TRIO, RTN4R, TRAFs, SQSTM1, BEX proteins, KIDINS220, NTRK receptors, and others, contribute to its diverse cellular functions.

Human

HEK293

N-Avi;N-6*His

P08138-1 (K29-N250)

4804  [NCBI]

Extracellular Domain

Biotin

KEACPTGLYTHSGECCKACNLGEGVAQPCGANQTVCEPCLDSVTFSDVVSATEPCKPCTECVGLQSMSAPCVEADDAVCRCAYGYYQDETTGRCEACRVCEAGSGLVFSCQDKQNTVCEECPDGTYSDEANHVDPCLPCTVCEDTERQLRECTRWADAECEEIPGRWITRSTPPEGSDSTAPSTQEPEAPPEQDLIASTVAGVVTTVMGSSQPVVTRGTTDN

≥ 90%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.