NGFR - nerve growth factor receptor Gene

Also Known as CD271; p75NTR; TNFRSF16; p75(NTR); Gp80-LNGFR

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4804

About NGFR

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:49,495,293-49,515,008 (from NCBI)

This gene has 3 transcripts (splice variants), 265 orthologues and 21 paralogues. Broad expression in spleen (RPKM 11.7), adrenal (RPKM 11.6) and 20 other tissues.

Summary

Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]

NGFR Products (1)

mRNA	Protein	Name
NM_002507.4	NP_002498.1	tumor necrosis factor receptor superfamily member 16 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calmodulin binding	IDA IDA: Inferred from direct assay	24914971	GOA
enables coreceptor activity	IDA IDA: Inferred from direct assay	16712417	GOA
enables death receptor activity	IGI IGI: Inferred from genetic interaction	11927634	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11756426	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	11279055	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Rho protein signal transduction	IDA IDA: Inferred from direct assay	16712417	GOA
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	26268439	GOA
involved in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IGI IGI: Inferred from genetic interaction	26268439	GOA
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	27927008	GOA
involved in neuron apoptotic process	IGI IGI: Inferred from genetic interaction	11927634	GOA
involved in positive regulation of miRNA transcription	IDA IDA: Inferred from direct assay	26268439	GOA
involved in positive regulation of protein localization to nucleus	IDA IDA: Inferred from direct assay	26268439	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	16712417	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NGFR Protein Structure

TNFR_c6

Death

0
100
200
300
400
427 a.a.

Protein Preferred Names	Protein Names
tumor necrosis factor receptor superfamily member 16	NGF receptor

NGFR Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NGFR	P08138	NGF	Homo sapiens	P01138	Crosslink	14985763
Intra	NGFR	P08138	NGF	Homo sapiens	P01138	SPR	14985763
Cross	NGFR	P08138	Ndn	Mus musculus	P25233	Anti Bait CoIP	14593116
Cross	NGFR	P08138	Ndn	Mus musculus	P25233	Anti Tag CoIP	14593116
Cross	NGFR	P08138	Ndn	Mus musculus	P25233	Pull Down	14593116
Intra	NGFR	P08138	TNFRSF21	Homo sapiens	O75509	Anti Bait CoIP	23559013
Intra	NGFR	P08138	TNFRSF21	Homo sapiens	O75509	Solid Phase Assay	23559013
Intra	NGFR	P08138	P05067-PRO_0000000093	Homo sapiens	P05067-PRO_0000000093	Anti Bait CoIP	11756426
Cross	NGFR	P08138	Nsmce3	Mus musculus	Q9CPR8	Anti Bait CoIP	14593116
Intra	NGFR	P08138	LINGO1	Homo sapiens	Q96FE5	Anti Bait CoIP	14966521

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NGFR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7271	NGFR Protein, Human (HEK293)	P08138-1 (K29-N250)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73318	NGFR Protein, Human (HEK293, Fc)	P08138-1 (K29-N250)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700613	NGFR Protein, Human (Biotinylated, HEK293, His-Avi)	P08138-1 (K29-N250)	≥ 90%, as determined by reducing SDS-PAGE.

NGFR Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81500	p75 NGF Receptor Antibody (YA1245)	IHC-P	Human
HY-P81500A	p75 NGF Receptor Antibody (YA1245)(PBS only)	IHC-P	Human
HY-P83029	p75 NGF Receptor Antibody (YA2774)	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P83029A	p75 NGF Receptor Antibody (YA2774)(PBS only)	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
HY-P83999	p75 NGF Receptor Antibody (YA3696)	ICC/IF, FC, ELISA	Human
HY-P83999A	p75 NGF Receptor Antibody (YA3696)(PBS only)	ICC/IF, FC, ELISA	Human
HY-P84000	p75 NGF Receptor Antibody (YA3697)	IHC-P, FC, ELISA	Human
HY-P84000A	p75 NGF Receptor Antibody (YA3697)(PBS only)	IHC-P, FC, ELISA	Human
HY-P85296	NGFR p75 Antibody (YA4988)	IHC-P; IHC-F; ICC/IF; IF-Tissue	Human, Rat, Mouse

Related Diseases

Diseases	Alias
Prurigo Nodularis	Nodular Prurigo Picker'S Nodules Hyde'S Disease
Diabetic Neuropathy	Diabetic Neuropathies
Anhidrosis	Hypohidrosis Absence Of Sweating Adiaphoresis Impaired Sweating Oligohidrosis
Prolactinoma	Prolactin-Producing Pituitary Gland Adenoma Prolactin-Secreting Pituitary Adenoma Forbes-Albright Syndrome Lactotroph Adenoma Prl-Secreting Pituitary Adenoma Prloma Pituitary Lactotrophic Adenoma Familial Prolactinoma Pituitary Adenoma, Prolactin-Secreting Prolactinoma Of Pituitary Gland PSPA
Olfactory Neuroblastoma	Esthesioneuroblastoma Asthesioneuroblastoma Esthesioneuroepithelioma Olfactory Esthesioneuroblastoma Paranasal Sinus Olfactory Neuroblastoma Esthesioneuroblastoma, Olfactory Esthesioneuroblastoma Of Nasal Cavity
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Mood Disorder	Mood Disorders Episodic Mood Disorder
Ocular Dominance
Tetraploidy	Tetraploidy Syndrome
Rabies	Lyssa Hydrophobia St Hubert Disease
Malignant Peripheral Nerve Sheath Tumor	Mpnst Malignant Neurilemmoma Neurofibrosarcoma Malignant Neurofibroma Malignant Schwannoma Neurogenic Sarcoma Schwannoma, Malignant Malignant Neoplasm Of The Peripheral Nerve Sheath Malignant Peripheral Nerve Sheath Tumors
Epithelioid Neurofibroma
Neuropathy, Hereditary Sensory And Autonomic, Type V	HSAN5 Hereditary Sensory And Autonomic Neuropathy Type V Hsan V Hereditary Sensory And Autonomic Neuropathy Type 5 Congenital Insensitivity To Pain Congenital Sensory Neuropathy With Selective Loss Of Small Myelinated Fibers Hsan Type V Insensitivity To Pain, Congenital Hereditary Sensory And Autonomic Neuropathy, Type 5 Congenital Insensitivity To Pain And Thermal Analgesia Neuropathy, Hereditary Sensory And Autonomic, 5 Hereditary Sensory Neuropathy Type V Hsn V Pain Insensitivity, Congenital Neuropathy, Sensory And Autonomic, Hereditary, Type V Hereditary Sensory Autonomic Neuropathy, Type 5 Hsan5 - [Hereditary Sensory And Autonomic Neuropathy Type 5]
Melanoma In Congenital Melanocytic Nevus	Malignant Melanoma In Congenital Melanocytic Nevus Melanocytic Nevi Nevi Melanocytic
Congenital Epulis	Gingival Neoplasms Congenital Epulides Congenital Gingival Cell Tumor Congenital Granular Cell Tumor Neumann Tumor
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Neurilemmoma	Schwannoma Benign Schwannoma Neurilemoma Peripheral Fibroblastoma Psammomatous Schwannoma Neurolemmoma Schwannomas
Autonomic Neuropathy	Diabetic Autonomic Neuropathy
Hemangiopericytoma, Malignant	Hemangiopericytoma Haemangiopericytic Meningioma Malignant Hemangiopericytoma Solitary Fibrous Tumor
Malignant Spindle Cell Melanoma	Spindle Cell Melanoma Desmoplastic Melanoma Spindle Cell Malignant Melanoma Spitzoid Malignant Melanoma
Congenital Granular Cell Tumor
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Epulis	Epulides Gingival Polyp Polyp Of Gum
Hypopharynx Cancer	Hypopharyngeal Cancer Malignant Neoplasm Of Hypopharynx Hypopharyngeal Neoplasms Hypopharyngeal Carcinoma Malignant Hypopharyngeal Tumor Malignant Tumor Of Hypopharynx Malignant Tumour Of Hypopharynx
Acoustic Neuroma	Neurofibromatosis Type 2 Vestibular Schwannoma Acoustic Neurinoma Bilateral Acoustic Neurofibromatosis Nf2 Acoustic Neurilemoma Cerebellopontine Angle Tumor Neurofibromatosis Central Type Neurofibromatosis Type Ii Vestibular Neurilemmoma Acoustic Tumor Neurinoma Of The Acoustic Nerve Acoustic Neurinoma Bilateral Acoustic Schwannomas Bilateral Banf Central Neurofibromatosis Familial Acoustic Neuromas Neurofibromatosis 2 Neurofibromatosis Type 2 Merlin Schwannoma, Acoustic, Bilateral Neuroma Acoustic Neuroma, Acoustic Familial Acoustic Neuroma Familial Vestibular Schwannoma Neurofibromatosis, Central Type Nf2 - [Neurofibromatosis Type 2]
Epithelioid Cell Melanoma	Epithelioid Melanoma
Breast Fibroadenoma	Fibroadenoma Fibroadenoma Of Breast Juvenile Fibroadenoma Of Breast Cellular Fibroadenoma Complex Fibroadenoma Of Breast Juvenile Fibroadenoma Fibroadenoma Nos Fibroadenoma Unspecified Site
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Hirschsprung Disease 1	Hirschsprung Disease Aganglionic Megacolon Hscr Hirschsprung'S Disease Congenital Megacolon Congenital Intestinal Aganglionosis Colonic Aganglionosis Hirschsprung Disease, Susceptibility To, 1 Hirschsprung Disease, Protection Against HSCR1 Mgc Pelvirectal Achalasia Total Intestinal Aganglionosis Megacolon, Aganglionic Macrocolon Hscr 1 Hirschsprung Disease Type 1 Hirschsprung Disease, Type 1 Congenital Dilatation Of Colon Aganglionosis Congenital Aganglionic Megacolon Aganglionosis Of Colon Bowel Aganglionosis Colon Aganglionosis Hirschsprung Megacolon
Intellectual Developmental Disorder, X-Linked 108	MRX108 X-Linked Intellectual Developmental Disorder 108 Mental Retardation, X-Linked 108 Mental Retardation, X-Linked, Type 108
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Melanoma, Uveal	Uveal Melanoma Choroidal Melanoma Melanoma Of Uvea Iris Melanoma Malignant Melanoma Of Choroid Malignant Melanoma Of Iris
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Neurofibromatosis, Type I	Von Recklinghausen Disease Neurofibromatosis 1 Neurofibromatosis, Type 1 NF1 Neurofibromatosis, Peripheral Type Neurofibromatosis Type I Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion Familial Spinal Neurofibromatosis Fsnf Peripheral Neurofibromatosis Von Recklinghausen'S Neurofibromatosis Von Recklinghausen Disease Due To Nf1 Mutation Or Intragenic Deletion Neurofibromatosis Peripheral Type Von Recklinghausen Syndrome Neurofibromatosis Type 1 Von Recklinghausen Neuropathy Nf1 - [Neurofibromatosis Type 1] Recklinghausen Disease
Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive	Charcot-Marie-Tooth Disease Type 4 Charcot-Marie-Tooth Disease Type 4e Hereditary Motor And Sensory Neuropathy Cmt4e CHN1 Hypomyelinating Neuropathy, Congenital, 1 Charcot-Marie-Tooth Neuropathy Type 4e Neuropathy, Congenital Hypomyelinating, 1 Ar-Cmt1 Autosomal Recessive Demyelinating Charcot-Marie-Tooth Cmt4 Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive Hypomyelination, Severe Congenital Charcot-Marie-Tooth Disease, Type 4e Charcot-Marie-Tooth Neuropathy, Type 4e Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy Autosomal Recessive Congenital Hypomyelinating Neuropathy Congenital Amyelinating Neuropathy Congenital Hypomyelinating Neuropathy Autosomal Recessive Neuropathy, Congenital Hypomyelinating Or Amyelinating Severe Congenital Hypomyelination Hereditary Sensory Motor Neuropathy Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive Neuropathy, Hypomyelinating, Congenital, Type 1 Neuropathy, Motor And Sensory, Hereditary Congenital Hypomyelinating Neuropathy Hereditary Motor And Sensory Neuropathies Hereditary Sensorimotor Neuropathy Hmsn - [Hereditary Motor And Sensory Neuropathy] Hsmn - [Hereditary Sensory And Motor Neuropathy] Hereditary Motor And Sensory Neuropathy, Types I-Iv
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111163	NSC49652	Inducer	98.74%	Unkown
HY-RS09278	NGFR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17166	Ngfr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23616	Ngfr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NGFR	VGNC	VGNC:99290
Mus musculus	NGFR	MGD	MGI:97323
Rattus norvegicus	NGFR	RGD	RGD:3177
Macaca mulatta	NGFR	VGNC	VGNC:75346
Canis familiaris	NGFR	VGNC	VGNC:55650
Bos taurus	NGFR	VGNC	VGNC:32062
Others	NGFR	NCBI