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p75 NGF Receptor Antibody (YA3696)

(Synonyms: CD271; p75NTR; TNFRSF16; p75(NTR); Gp80-LNGFR; NGFR)
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p75 NGF Receptor Antibody (YA3696) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to p75 NGF Receptor.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    ICC/IF, FC, ELISA

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS with 0.05% sodium azide.

  • Conjugation:
    Non-conjugated
  • p75 NGF Receptor Antibody (YA3696) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
FC Info
FC: Flow Cytometry
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:200-1:1000 1:200-1:400 1:10000

Product Details

Description

p75 NGF Receptor Antibody (YA3696) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to p75 NGF Receptor.

  • Host Mouse
  • Clonality Monoclonal
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 70-75 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 45 kDa
Immunogen

Purified recombinant fragment of human NGFR aa 1-200 .

Purification

affinity purified.

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS with 0.05% sodium azide.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    p75 NGF Receptor is a Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF. Plays an important role in differentiation and survival of specific neuronal populations during development. Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA. Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake. Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver. Together with BFAR negatively regulates NF-kappa-B and JNK-related signaling pathways[1][2][3][4].

  • Subcellular Localization

    Cell membrane; Single-pass type I membrane protein; Cytoplasm; Perikaryon; Cell projection, growth cone; Cell projection, dendritic spine

  • Isoforms & Post-Translational Modification

    P08138 has 2 isomers: P08138-1: 45183 Da (predicted); P08138-2: 35767 Da (predicted).
    N- and O-glycosylated;O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc;Phosphorylated on serine residues

  • Subunit

    Homodimer; disulfide-linked (By similarity). Heterodimer with SORCS2. The extracellular domains of the heterodimer bind NGF (PubMed:22155786, PubMed:24908487).

  • SwissProt ID

    P08138

  • Gene ID
    4804 [NCBI]
  • Synonyms

    CD271; p75NTR; TNFRSF16; p75(NTR); Gp80-LNGFR; NGFR

p75 NGF Receptor Antibody (YA3696) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • p75 NGF Receptor Antibody (YA3696) Product Image
    1/16
  • p75 NGF Receptor Antibody (YA3696) Product Image