2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. TNF Superfamily
  5. TNF Receptor Superfamily
  6. Death Receptor 6

Death Receptor 6

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Cat. No. Product Name / Synonyms Species Source
  • HY-P77352
    DR6/TNFRSF21 Protein, Cynomolgus (HEK293, His)

    Tumor necrosis factor receptor superfamily member 21; CD358; Tnfrsf21; DR6

    		Cynomolgus HEK293
    Tnfrsf21 Protein, also known as death receptor 6 (DR6), CD358, or BM-018, is highly expressed in differentiating neurons as well as in the adult brain, and is upregulated in injured neurons. DR6 negatively regulates neuron, axon, and oligodendrocyte survival, hinders axondendrocyte and oligodendrocyte regeneration and its inhibition has a neuro-protective effect in nerve injury. It activates nuclear factor kappa-B (NFkB) and mitogen-activated protein kinase 8 (MAPK8, also called c-Jun N-terminal kinase 1), and induces cell apoptosis by associating with TNFRSF1A-associated via death domain (TRADD), which is known to mediate signal transduction of tumor necrosis factor receptors. DR6/TNFRSF21 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived DR6/TNFRSF21 protein, expressed by HEK293 , with C-His labeled tag. The total length of DR6/TNFRSF21 Protein, Cynomolgus (HEK293, His) is 309 a.a., with molecular weight of ~55-75 KDa.
  • HY-P75277
    DR6/TNFRSF21 Protein, Rat (HEK293, Fc)

    Tumor necrosis factor receptor superfamily member 21; CD358; Tnfrsf21; DR6

    		Rat HEK293
    DR6/TNFRSF21 protein is the core of apoptosis and may activate NF-kappa-B and promote BAX-mediated apoptosis through cytochrome c release. In neuronal apoptosis, it responds to amyloid peptides in APP, which is critical for cell body death and axonal pruning. DR6/TNFRSF21 Protein, Rat (HEK293, Fc) is the recombinant rat-derived DR6/TNFRSF21 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of DR6/TNFRSF21 Protein, Rat (HEK293, Fc) is 349 a.a., with molecular weight of ~95-115 kDa.
  • HY-P72979
    DR6/TNFRSF21 Protein, Human (HEK293, Fc)

    Tumor necrosis factor receptor superfamily member 21; CD358; Tnfrsf21; DR6

    		Human HEK293
    DR6/TNFRSF21 protein is the core protein of apoptosis and can activate NF-kappa-B, BAX-mediated apoptosis and mitochondrial cytochrome c release. In neuronal apoptosis, it is critical for amyloid peptide-triggered cell body death and axonal pruning. DR6/TNFRSF21 Protein, Human (HEK293, Fc) is the recombinant human-derived DR6/TNFRSF21 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of DR6/TNFRSF21 Protein, Human (HEK293, Fc) is 350 a.a., with molecular weight of 95-100 kDa.
  • HY-P75278
    DR6/TNFRSF21 Protein, Mouse (349a.a, HEK293, His)

    Tumor necrosis factor receptor superfamily member 21; CD358; Tnfrsf21; DR6

    		Mouse HEK293
    The DR6/TNFRSF21 protein participates in multiple cellular processes and promotes apoptosis through NF-kappa-B activation, BAX-mediated pathways, and cytochrome c release. It is critical for neuronal apoptosis, particularly in response to APP-derived amyloid peptides, and is critical for normal cell body death and axonal pruning. DR6/TNFRSF21 Protein, Mouse (349a.a, HEK293, His) is the recombinant mouse-derived DR6/TNFRSF21 protein, expressed by HEK293 , with C-His labeled tag. The total length of DR6/TNFRSF21 Protein, Mouse (349a.a, HEK293, His) is 349 a.a., with molecular weight of 55-60 kDa.
  • HY-P72665
    DR6/TNFRSF21 Protein, Human (309a.a, HEK293, His)

    Tumor necrosis factor receptor superfamily member 21; CD358; Tnfrsf21; DR6

    		Human HEK293
    DR6/TNFRSF21 protein is the core protein of apoptosis and can activate NF-kappa-B, BAX-mediated apoptosis and mitochondrial cytochrome c release. In neuronal apoptosis, it is critical for amyloid peptide-triggered cell body death and axonal pruning. DR6/TNFRSF21 Protein, Human (309a.a, HEK293, His) is the recombinant human-derived DR6/TNFRSF21 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of DR6/TNFRSF21 Protein, Human (309a.a, HEK293, His) is 309 a.a., with molecular weight of ~58 kDa.
  • HY-P75279
    DR6/TNFRSF21 Protein, Human (HEK293)

    Tumor necrosis factor receptor superfamily member 21; CD358; Tnfrsf21; DR6

    		Human HEK293
    DR6/TNFRSF21 protein is the core protein of apoptosis and can activate NF-kappa-B, BAX-mediated apoptosis and mitochondrial cytochrome c release. In neuronal apoptosis, it is critical for amyloid peptide-triggered cell body death and axonal pruning. DR6/TNFRSF21 Protein, Human (HEK293) is the recombinant human-derived DR6/TNFRSF21 protein, expressed by HEK293 , with tag free. The total length of DR6/TNFRSF21 Protein, Human (HEK293) is 350 a.a., with molecular weight of 55-60 kDa.
  • HY-P72664
    DR6/TNFRSF21 Protein, Mouse (HEK293, Fc-His)

    Tumor necrosis factor receptor superfamily member 21; CD358; Tnfrsf21; DR6

    		Mouse HEK293
    The DR6/TNFRSF21 protein participates in multiple cellular processes and promotes apoptosis through NF-kappa-B activation, BAX-mediated pathways, and cytochrome c release. It is critical for neuronal apoptosis, particularly in response to APP-derived amyloid peptides, and is critical for normal cell body death and axonal pruning. DR6/TNFRSF21 Protein, Mouse (HEK293, Fc-His) is the recombinant mouse-derived DR6/TNFRSF21 protein, expressed by HEK293 , with C-hFc, C-6*His labeled tag. The total length of DR6/TNFRSF21 Protein, Mouse (HEK293, Fc-His) is 308 a.a., with molecular weight of 75-120 kDa.
  • HY-P700505
    DR6/TNFRSF21 Protein, Human (His-SUMO)

    Death receptor 6; CD358

    		Human E. coli
    DR6/TNFRSF21 Protein, central to apoptosis, activates NF-kappa-B, BAX-mediated apoptosis, and mitochondrial cytochrome c release. In neuronal apoptosis, it's pivotal for amyloid peptide-triggered cell body death and axonal pruning. It negatively regulates oligodendrocyte survival, maturation, and myelination. In T-cell signaling, it's crucial for differentiation, proliferation, and immune response, inhibiting T-cell cytokine release and Ig production. Additionally, it regulates pyroptosis by recruiting CASP8 upon ROS stimulation. Interactions include NGFR, CASP8, N-APP, and association with TRADD. DR6/TNFRSF21 Protein, Human (His-SUMO) is the recombinant human-derived DR6/TNFRSF21 protein, expressed by E. coli, with N-SUMO, N-6*His labeled tag. The total length of DR6/TNFRSF21 Protein, Human (His-SUMO) is 285 a.a., with molecular weight of 48 kDa.
Cat. No. Product Name Effect Purity