DR6/TNFRSF21 Protein, Human (His-SUMO)
DR6/TNFRSF21 protein is the core protein of apoptosis and can activate NF-kappa-B, BAX-mediated apoptosis and mitochondrial cytochrome c release.In neuronal apoptosis, it is critical for amyloid peptide-triggered cell body death and axonal pruning.DR6/TNFRSF21 Protein, Human (His-SUMO) is the recombinant human-derived DR6/TNFRSF21 protein, expressed by E.coli , with N-SUMO, N-6*His labeled tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
DR6/TNFRSF21 protein is the core protein of apoptosis and can activate NF-kappa-B, BAX-mediated apoptosis and mitochondrial cytochrome c release.In neuronal apoptosis, it is critical for amyloid peptide-triggered cell body death and axonal pruning.DR6/TNFRSF21 Protein, Human (His-SUMO) is the recombinant human-derived DR6/TNFRSF21 protein, expressed by E.coli , with N-SUMO, N-6*His labeled tag.
Background
The DR6/TNFRSF21 Protein has multiple roles in promoting apoptosis, including activation of NF-kappa-B and apoptosis mediated by BAX and cytochrome c release from the mitochondria. It is involved in neuronal apoptosis triggered by amyloid peptides, contributing to both cell body death and axonal pruning. Additionally, it negatively regulates oligodendrocyte survival, maturation, and myelination. The protein also plays a crucial role in T-cell signaling, adaptive immune response, and the regulation of T-cell differentiation and proliferation. It inhibits T-cell responses and the release of cytokines, as well as the production of IgG, IgM, and IgM in response to antigens. Furthermore, it acts as a regulator of pyroptosis, recruiting CASP8 upon reactive oxygen species (ROS) stimulation and oxidation, leading to GSDMC activation. The DR6/TNFRSF21 Protein interacts with NGFR, CASP8, and N-APP and associates with TRADD.
Technical Parameters
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Species Human
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Source E. coli
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Tag N-SUMO;N-6*His
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Accession
O75509 (R371-L655)
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Molecular Construction
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N-term
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6*His-SUMO
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DR6 (R371-L655)
Accession # O75509 -
C-term
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Protein Length
Cytoplasmic Domain
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Synonyms
TNFRSF21; BM-018; TNF Receptor Superfamily Member 21; Tumor Necrosis Factor Receptor Superfamily, Member 21; DR6; TNFR-Related Death Receptor 6; Death Receptor 6; Alternative Protein TNFRSF21; CD358; TNFRSF21 Protein; Tumor Necrosis Factor Receptor Superf
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AA Sequence
RKSSRTLKKGPRQDPSAIVEKAGLKKSMTPTQNREKWIYYCNGHGIDILKLVAAQVGSQWKDIYQFLCNASEREVAAFSNGYTADHERAYAALQHWTIRGPEASLAQLISALRQHRRNDVVEKIRGLMEDTTQLETDKLALPMSPSPLSPSPIPSPNAKLENSALLTVEPSPQDKNKGFFVDESEPLLRCDSTSSGSSALSRNGSFITKEKKDTVLRQVRLDPCDLQPIFDDMLHFLNPEELRVIEEIPQAEDKLDRLFEIIGVKSQEASQTLLDSVYSHLPDLL
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Predicted Molecular Mass
48 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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