DR6/TNFRSF21 Protein, Human (His-SUMO)

DR6/TNFRSF21 Protein, central to apoptosis, activates NF-kappa-B, BAX-mediated apoptosis, and mitochondrial cytochrome c release. In neuronal apoptosis, it's pivotal for amyloid peptide-triggered cell body death and axonal pruning. It negatively regulates oligodendrocyte survival, maturation, and myelination. In T-cell signaling, it's crucial for differentiation, proliferation, and immune response, inhibiting T-cell cytokine release and Ig production. Additionally, it regulates pyroptosis by recruiting CASP8 upon ROS stimulation. Interactions include NGFR, CASP8, N-APP, and association with TRADD. DR6/TNFRSF21 Protein, Human (His-SUMO) is the recombinant human-derived DR6/TNFRSF21 protein, expressed by E. coli, with N-SUMO, N-6*His labeled tag. The total length of DR6/TNFRSF21 Protein, Human (His-SUMO) is 285 a.a., with molecular weight of 48 kDa.

The DR6/TNFRSF21 Protein has multiple roles in promoting apoptosis, including activation of NF-kappa-B and apoptosis mediated by BAX and cytochrome c release from the mitochondria. It is involved in neuronal apoptosis triggered by amyloid peptides, contributing to both cell body death and axonal pruning. Additionally, it negatively regulates oligodendrocyte survival, maturation, and myelination. The protein also plays a crucial role in T-cell signaling, adaptive immune response, and the regulation of T-cell differentiation and proliferation. It inhibits T-cell responses and the release of cytokines, as well as the production of IgG, IgM, and IgM in response to antigens. Furthermore, it acts as a regulator of pyroptosis, recruiting CASP8 upon reactive oxygen species (ROS) stimulation and oxidation, leading to GSDMC activation. The DR6/TNFRSF21 Protein interacts with NGFR, CASP8, and N-APP and associates with TRADD.

Human

E. coli

N-SUMO;N-6*His

O75509 (R371-L655)

27242  [NCBI]

RKSSRTLKKGPRQDPSAIVEKAGLKKSMTPTQNREKWIYYCNGHGIDILKLVAAQVGSQWKDIYQFLCNASEREVAAFSNGYTADHERAYAALQHWTIRGPEASLAQLISALRQHRRNDVVEKIRGLMEDTTQLETDKLALPMSPSPLSPSPIPSPNAKLENSALLTVEPSPQDKNKGFFVDESEPLLRCDSTSSGSSALSRNGSFITKEKKDTVLRQVRLDPCDLQPIFDDMLHFLNPEELRVIEEIPQAEDKLDRLFEIIGVKSQEASQTLLDSVYSHLPDLL

48 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.