TNFRSF21 - TNF receptor superfamily member 21 Gene

Also Known as DR6; CD358; BM-018

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27242

About TNFRSF21

Cytogenetic location: 6p12.3 Genomic coordinates (GRCh38): 6:47,231,532-47,309,905 (from NCBI)

This gene has 1 transcript (splice variant), 212 orthologues and 21 paralogues. Broad expression in urinary bladder (RPKM 50.6), fat (RPKM 36.4) and 23 other tissues.

Summary

This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell Apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013]

TNFRSF21 Products (1)

mRNA Protein Name
NM_014452.5 NP_055267.1 tumor necrosis factor receptor superfamily member 21 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23559013 GOA
Biological Process GO Annotation Evidence References Source
involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
22761420 GOA
involved in cellular response to tumor necrosis factor IDA
IDA: Inferred from direct assay
19654028 GOA
involved in negative regulation of myelination IMP
IMP: Inferred from mutant phenotype
21725297 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
19654028 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFRSF21 Protein Structure

Death

Death: Death domain (418 - 495)

  • 0
  • 200
  • 400
  • 600
  • 655 a.a.
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 21

  • TNFR-related death receptor 6

TNFRSF21 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TNFRSF21 O75509 NGFR Homo sapiens P08138
Solid Phase Assay
23559013
Intra
TNFRSF21 O75509 SGTA Homo sapiens O43765
Y2H Prey Pooling
32296183
Intra
TNFRSF21 O75509 SGTA Homo sapiens O43765
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TNFRSF21 Proteins

Cat. No. Product Name Accession Purity
HY-P72665 DR6/TNFRSF21 Protein, Human (HEK293, His) O75509 (Q42-L350) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72979 DR6/TNFRSF21 Protein, Human (HEK293, Fc) O75509 (Q42-L350) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75279 DR6/TNFRSF21 Protein, Human (HEK293) O75509 (Q42-L350) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700505 DR6/TNFRSF21 Protein, Human (His-SUMO) O75509 (R371-L655) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Diffuse Infiltrative Lymphocytosis Syndrome
Nipah Virus Encephalitis

  • Equine Morbillivirus
Robinow Syndrome, Autosomal Dominant 1

  • Autosomal Dominant Robinow Syndrome 1

  • DRS1

  • Robinow Dwarfism

  • Fetal Face Syndrome

  • Acral Dysostosis With Facial And Genital Abnormalities

  • Robinow, Autosomal Dominant Syndrome, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14812 TNFRSF21 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18109 Tnfrsf21 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24583 Tnfrsf21 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990526 Anti-TNFRSF21/DR6/CD358 Antibody Inhibitor 98.58% Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TNFRSF21 VGNC VGNC:78923
Rattus norvegicus TNFRSF21 RGD RGD:1307308
Bos taurus TNFRSF21 VGNC VGNC:36166
Felis catus TNFRSF21 VGNC VGNC:66409
Mus musculus TNFRSF21 MGD MGI:2151075
Macaca fascicularis TNFRSF21 NCBI NCBI:101925746
Others TNFRSF21 NCBI