2. Gene
  3. TNFRSF21 - TNF receptor superfamily member 21 Gene

TNFRSF21 - TNF receptor superfamily member 21 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DR6; CD358; BM-018

Gene ID: 27242 | Gene type: protein coding

About TNFRSF21

Cytogenetic location: 6p12.3 Genomic coordinates (GRCh38): 6:47,231,532-47,309,905 (from NCBI)

This gene has 1 transcript (splice variant), 212 orthologues and 21 paralogues. Broad expression in urinary bladder (RPKM 50.6), fat (RPKM 36.4) and 23 other tissues.

Summary

This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell Apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013]

TNFRSF21 Products(1)

mRNA Protein Name
NM_014452.5 NP_055267.1 tumor necrosis factor receptor superfamily member 21 precursor

TNFRSF21 Protein Structure

Death

Death: Death domain (418 - 495)

  • 0
  • 200
  • 400
  • 600
  • 655 a.a.
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 21

TNFR-related death receptor 6

Recombinant TNFRSF21 Proteins

Cat. No. Product Name Accession Purity
HY-P72665 DR6/TNFRSF21 Protein, Human (309a.a, HEK293, His) O75509 (Q42-L350) ≥95%
HY-P73515 DR6/TNFRSF21 Protein, Human (350a.a, HEK293, His) O75509 (M1-L350) ≥95%
HY-P72979 DR6/TNFRSF21 Protein, Human (HEK293, Fc) O75509 (M1-L350) ≥95%
HY-P75279 DR6/TNFRSF21 Protein, Human (HEK293) O75509 (M1-L350) ≥95%
HY-P700505 DR6/TNFRSF21 Protein, Human (His-SUMO) O75509 (R371-L655) ≥95%

Related Diseases

Diseases Alias
Diffuse Infiltrative Lymphocytosis Syndrome
Nipah Virus Encephalitis

Equine Morbillivirus
Robinow Syndrome, Autosomal Dominant 1

Autosomal Dominant Robinow Syndrome 1

DRS1

Robinow Dwarfism

Fetal Face Syndrome

Acral Dysostosis With Facial And Genital Abnormalities

Robinow, Autosomal Dominant Syndrome, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14812 TNFRSF21 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TNFRSF21 VGNC VGNC:78923
Rattus norvegicus TNFRSF21 RGD RGD:1307308
Bos taurus TNFRSF21 VGNC VGNC:36166
Felis catus TNFRSF21 VGNC VGNC:66409
Mus musculus TNFRSF21 MGD MGI:2151075
Macaca fascicularis TNFRSF21 NCBI
Others TNFRSF21 NCBI