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Prostaglandin F2α Metabolite

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By Targets:	Drug Metabolite (4) Endogenous Metabolite (9) Prostaglandin Receptor (9) Angiotensin Receptor (1) Drug Derivative (3) Isotope-Labeled Compounds (2) Reference Standards (1)
By Research Areas:	Cardiovascular Disease (4) Endocrinology (5) Inflammation/Immunology (4) Metabolic Disease (4) Neurological Disease (2)

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Isotope-Labeled Compounds

Targets Recommended: Prostaglandin Receptor Drug Metabolite Endogenous Metabolite PGE synthase

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-19518

Latanoprostene bunod NCX116; LBN	Prostaglandin Receptor	Neurological Disease
Latanoprostene bunod (NCX116; LBN) is a nitric oxide-releasing prostaglandin F₂α analog. Latanoprostene bunod is a prodrug that, upon instillation into the eye, is hydrolyzed by corneal esterases into two active metabolites: Latanoprost (HY-B0577) and NO. Latanoprost activates the prostaglandin FP receptor to increase the outflow of aqueous humor through the uveoscleral pathway. NO increases aqueous humor drainage through the trabecular meshwork pathway, achieving synergistic enhancement targeting the dual pathways of aqueous humor outflow. Latanoprostene bunod can be used in research related to open-angle glaucoma and ocular hypertension .

HY-129953

9α,11β-Prostaglandin F2α 9α,11β-PGF2α	Endogenous Metabolite	Inflammation/Immunology
9α,11β-Prostaglandin F₂α (9α,11β-PGF2α) is an endogenous metabolite present in urine, which can be used for asthma research .

HY-113208

13,14-Dihydro-15-keto Prostaglandin F2α 13,14-Dihydro-15-keto-PGF2α	Endogenous Metabolite	Others
13,14-Dihydro-15-keto Prostaglandin F2α (13,14-Dihydro-15-keto-PGF2α) is an endogenous metabolite present in Blood that can be used for the research of Pregnancy .

HY-129953A

5-trans Prostaglandin F2α 5-trans PGF2α	Endogenous Metabolite	Cardiovascular Disease
5-trans Prostaglandin F2α is an endogenous metabolite present in Blood that can be used for the research of Myocardial Infarction .

HY-118816

11β-Prostaglandin F2α 11-epi PGF2α-EA; 11β-PGF2α-EA; 11β-Prostamide F2α	Drug Metabolite	Metabolic Disease
11β-Prostaglandin F2α ethanolamide (11β-PGF2α-EA) is the theoretical hepatic metabolite of PGD2-EA, produced during COX-2 metabolism of the endogenous cannabinoid AEA which is found in brain, liver, and other mammalian tissues.1 AEA can be used directly by COX-2 and specific PG synthase to produce ethanolamide congeners of the classical PGs. PGD2-EA is formed in activated RAW 264.7 cells treated with AEA.

HY-113246

15-keto-Prostaglandin F2a 15-keto-PGF2α	Prostaglandin Receptor Endogenous Metabolite	Endocrinology
15-keto-Prostaglandin F2α (15-keto-PGF2α) is a metabolite of Prostaglandin F2α. Prostaglandin F2α. Prostaglandin F2α is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist and plays a key role in the onset and progression of labour .

HY-19518R

Latanoprostene bunod (Standard) NCX116 (Standard); LBN (Standard)	Reference Standards Prostaglandin Receptor	Neurological Disease
Latanoprostene bunod (NCX116; LBN) (Standard) is the analytical standard of Latanoprostene bunod. This product is intended for research and analytical applications. Latanoprostene bunod is a nitric oxide-releasing prostaglandin F₂α analog. Latanoprostene bunod is a prodrug that, upon instillation into the eye, is hydrolyzed by corneal esterases into two active metabolites: Latanoprost (HY-B0577) and NO. Latanoprost activates the prostaglandin FP receptor to increase the outflow of aqueous humor through the uveoscleral pathway. NO increases aqueous humor drainage through the trabecular meshwork pathway, achieving synergistic enhancement targeting the dual pathways of aqueous humor outflow. Latanoprostene bunod can be used in research related to open-angle glaucoma and ocular hypertension.

HY-129953B

15(R)-Prostaglandin F2α 15(R)-PGF2α	Endogenous Metabolite	Inflammation/Immunology
15(R)-Prostaglandin F2α is the isomer of 9α,11β-Prostaglandin F2α (HY-129953). 9α,11β-Prostaglandin F2α is an endogenous metabolite present in Urine that can be used for the research of Asthma .

HY-129953S

9α,11β-Prostaglandin F2α-d4 9α,11β-PGF2α-d-d₄	Isotope-Labeled Compounds Endogenous Metabolite	Inflammation/Immunology
9α,11β-Prostaglandin F2α-d4 is a deuterated labeled 9α,11β-Prostaglandin F2α . 9α,11β-Prostaglandin F2α is an endogenous metabolite present in Urine that can be used for the research of Asthma .

HY-158595

15(R),19(R)-Hydroxy prostaglandin F2α 15(R),19(R)-Hydroxy PGF2α	Drug Derivative	Others
15(R),19(R)-Hydroxy prostaglandin F2α (15(R),19(R)-Hydroxy PGF2α) is an analog of 19(R)-Hydroxy-prostaglandin F2α. 19(R)-Hydroxy-prostaglandin F2α (HY-N7857) is an ω-1 hydroxylase metabolite of PGF2α found in human semen .

HY-139121

15(R)-17-Phenyl trinor Prostaglandin F2α 15-epi Bimatoprost free acid; 15(R)-Bimatoprost free acid; 15(R)-17-phenyl trinor PGF2α	Prostaglandin Receptor	Endocrinology
15(R)-17-Phenyl trinor Prostaglandin F2α (15-epi Bimatoprost free acid) is a prostaglandin F (FP) analog that acts as an ocular hypotensive agent. The free acid 17-Phenyl trinor Prostaglandin F2α is a potent FP receptor agonist. 15(R)-17-Phenyl trinor Prostaglandin F2α is the 15-epi or "unnatural" isomer of this active free acid metabolite and has reduced FP receptor agonist activity.

HY-N7857

19(R)-Hydroxy-prostaglandin F2α 19(R)-Hydroxy PGF2α	Drug Metabolite	Metabolic Disease
19(R)-Hydroxy-prostaglandin F2α (19(R)-hydroxy PGF2α) is an ω-1 hydroxylase metabolite of PGF2α found in human semen. The concentration of 19(R)-Hydroxy-PGFs compounds (F2α and F1α together) in fresh human semen is about 20 μg/mL. 19(R)-Hydroxy-prostaglandin F2α exhibits no activity at the FP receptor of the cat iris sphincter muscle at concentrations up to 1 μM.

HY-113459S1

13,14-Dihydro-15-keto Prostaglandin F2α-d4 13,14-Dihydro-15-keto-PGF2α-d₄	Isotope-Labeled Compounds Prostaglandin Receptor	Endocrinology
13,14-Dihydro-15-keto Prostaglandin F2α-d4 (13,14-Dihydro-15-keto-PGF2α-d4) is a deuterated labeled 13,14-Dihydro-15-keto Prostaglandin F2α (HY-113208). 13,14-Dihydro-15-keto Prostaglandin F2α-d4 is an endogenous metabolite present in Blood that can be used for the research of Pregnancy .

HY-113778

15-keto-17-phenyl trinor Prostaglandin F2α 15-keto-17-phenyl trinor PGF2α	Prostaglandin Receptor	Endocrinology
15-keto-17-phenyl trinor Prostaglandin F2α (15-keto-17-phenyl trinor PGF2α) is an F-series prostaglandin (PG) analog. The potential metabolite of 15-keto-17-phenyl trinor Prostaglandin F2α in animals is 15-keto PG. 15-keto PG can slightly reduce the intraocular pressure (1 mm Hg) in normal cynomolgus monkeys when administered at a dose of 1 μg/eye. 15-keto-17-phenyl trinor Prostaglandin F2α is a miotic agent in cats, reducing the pupil diameter by 8 mm at a dose of 5 μg/eye.

HY-137504

20-ethyl Prostaglandin F2α ICI 74205; 20-ethyl PGF2α	Prostaglandin Receptor Drug Metabolite	Metabolic Disease
20-ethyl Prostaglandin F2α (ICI 74205; 20-ethyl PGF2α) is an analog of PGF2α and an arachidonic acid (HY-109590) metabolite.

HY-114687

5,7-Dihydroxy-11-ketotetranorprostanoic acid	Endogenous Metabolite	Cardiovascular Disease Others
5,7-Dihydroxy-11-ketotetranorprostanoic acid is a urinary metabolite of prostaglandin F_2α and precursor to tetranor-PGF metabolites, exhibits hardly activity in blood pressure assay and smooth muscle stiumulation assay .

HY-137024

15-Keto-PGA1	Angiotensin Receptor	Cardiovascular Disease
15-Keto-PGA1 is a metabolite of PGA1 and has significant vasoconstrictive effects. PGA1 is also a vasoconstrictor and is more potent than equivalent doses of prostaglandin F2α (PGF2α) and angiotensin II .

HY-113208A

11β-13,14-Dihydro-15-keto Prostaglandin F2α 11β-13,14-Dihydro-15-keto PGF2α; 11-epi-13,14-dihydro-15-keto PGF2α	Endogenous Metabolite	Others
11β-13,14-Dihydro-15-keto Prostaglandin F2α is the deviative of 13,14-Dihydro-15-keto PGF2a (HY-113208), which is an endogenous metabolite present in Blood that can be used for the research of Pregnancy .

HY-137547

20-Hydroxy-PGF2α	Prostaglandin Receptor	Metabolic Disease
20-hydroxy Prostaglandin F2α (20-hydroxy PGF2α) is the ω-oxidation product of PGF2α. Cultured type II alveolar cells from pregnant rabbits metabolize exogenous PGF2α via microsomal cytochrome P450 ω-oxidation, producing 20-hydroxy PGF2α and its 15-hydroxy PGDH metabolites. Cells from male rabbits exhibit only the 15-hydroxy PGDH pathway.

HY-129953C

5-trans Prostaglandin F2α tromethamine 5-trans PGF2α tromethamine	Drug Derivative	Cardiovascular Disease
5-trans Prostaglandin F2α tromethamine is a derivative of 5-trans Prostaglandin F2α (HY-129953A). 5-trans Prostaglandin F2α is an endogenous metabolite present in blood that can be used for the research of myocardial infarction .

HY-W746889

17-Phenyl trinor prostaglandin F2α 1,15-lactone 17-Phenyl trinor PGF2α 1,15-lactone	Drug Derivative	Others
17-Phenyl trinor prostaglandin F2α 1,15-lactone (17-Phenyl trinor PGF2α 1,15-lactone) is a 1,15 lactone of 17-Phenyl trinor prostaglandin F2α. 17-Phenyl trinor prostaglandin F2α is a metabolite of Dinoprost (HY-12956) .

HY-116889

15-Keto latanoprost acid	Drug Metabolite	Others
15-keto Latanoprost is a potential metabolite of latanoprost (HY-B0577) when administered to animals. 15-keto Latanoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. Although much less potent that the parent compound latanoprost, 15-keto latanoprost still retains the ability to produce a small but measurable decrease (1 mm Hg) in the intraocular pressure of normal cynomolgus monkeys when administered at a dose of 1 μg/eye.1 15-keto Latanoprost is also a miotic in the normal cat eye, causing an 8 mm Hg reduction in pupillary diameter at 5 μg/eye. Again, this is not as potent as many other F-type prostaglandins; for example, prostaglandin F2α will produce this degree of miosis at a dose of less than 1 μg/eye.

HY-W408869

8-iso-13,14-dihydro-15-keto Prostaglandin F2α	Endogenous Metabolite	Inflammation/Immunology
8-iso-13,14-dihydro-15-keto Prostaglandin F2α is an oxidative metabolite of 8-iso-prostaglandin F_2α (HY-113209). 8-iso-13,14-dihydro-15-keto Prostaglandin F2α can be used in the study of oxidative stress-related diseases .

HY-129397

2,3-Dinor-11beta-prostaglandin F2alpha BPG; 2,3-Dinor-11β-PGF2α; 2,3-dinor-11-epi PGF2α	Prostaglandin Receptor	Endocrinology
2,3-Dinor-11beta-prostaglandin F2alpha (2,3-Dinor-11β-PGF2α) is a metabolite of PGD2. Urinary excretion of 2,3-Dinor-11beta-prostaglandin F2alpha is increased in patients with mast cell activation disease (MCAD) and has been used as a marker of increased PGD2 levels. 2,3-Dinor-11beta-prostaglandin F2alpha levels are also increased in the urine of patients with asthma and are positively correlated with impaired lung function.

Cat. No.	상품명	Category	Target	Chemical Structure

HY-129953

9α,11β-Prostaglandin F2α 9α,11β-PGF2α	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite
9α,11β-Prostaglandin F₂α (9α,11β-PGF2α) is an endogenous metabolite present in urine, which can be used for asthma research .

HY-113208

13,14-Dihydro-15-keto Prostaglandin F2α 13,14-Dihydro-15-keto-PGF2α	Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
13,14-Dihydro-15-keto Prostaglandin F2α (13,14-Dihydro-15-keto-PGF2α) is an endogenous metabolite present in Blood that can be used for the research of Pregnancy .

HY-113246

15-keto-Prostaglandin F2a 15-keto-PGF2α	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Prostaglandin Receptor Endogenous Metabolite
15-keto-Prostaglandin F2α (15-keto-PGF2α) is a metabolite of Prostaglandin F2α. Prostaglandin F2α. Prostaglandin F2α is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist and plays a key role in the onset and progression of labour .

Cat. No.	상품명	Chemical Structure

HY-129953S

9α,11β-Prostaglandin F2α-d4
9α,11β-Prostaglandin F2α-d4 is a deuterated labeled 9α,11β-Prostaglandin F2α . 9α,11β-Prostaglandin F2α is an endogenous metabolite present in Urine that can be used for the research of Asthma .

HY-113459S1

13,14-Dihydro-15-keto Prostaglandin F2α-d4
13,14-Dihydro-15-keto Prostaglandin F2α-d4 (13,14-Dihydro-15-keto-PGF2α-d4) is a deuterated labeled 13,14-Dihydro-15-keto Prostaglandin F2α (HY-113208). 13,14-Dihydro-15-keto Prostaglandin F2α-d4 is an endogenous metabolite present in Blood that can be used for the research of Pregnancy .

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Prostaglandin F2α Metabolite

Inhibitors & Agonists

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Isotope-Labeled Compounds

Natural
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