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Latanoprostene bunod (Synonyms: NCX116; LBN)

Cat. No.: HY-19518 Purity: 99.85%
Handling Instructions

Latanoprostene bunod (LBN), a nitric oxide (NO)-donating prostaglandin F2a analog, is a topical ophthalmic therapeutic for the reduction of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension (OHT) .

For research use only. We do not sell to patients.

Latanoprostene bunod Chemical Structure

Latanoprostene bunod Chemical Structure

CAS No. : 860005-21-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 257 In-stock
Estimated Time of Arrival: December 31
1 mg USD 90 In-stock
Estimated Time of Arrival: December 31
5 mg USD 230 In-stock
Estimated Time of Arrival: December 31
10 mg USD 400 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Latanoprostene bunod (LBN), a nitric oxide (NO)-donating prostaglandin F2a analog, is a topical ophthalmic therapeutic for the reduction of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension (OHT) [1].

Clinical Trial
Molecular Weight

507.62

Formula

C₂₇H₄₁NO₈

CAS No.

860005-21-6

SMILES

O=C(OCCCCO[N+]([O-])=O)CCC/C=C\C[[email protected]@H]1[[email protected]@H](CC[[email protected]@H](O)CCC2=CC=CC=C2)[[email protected]](O)C[[email protected]@H]1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (492.49 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9700 mL 9.8499 mL 19.6998 mL
5 mM 0.3940 mL 1.9700 mL 3.9400 mL
10 mM 0.1970 mL 0.9850 mL 1.9700 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.10 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.10 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.10 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

Latanoprostene bunodNCX116LBNNCX 116NCX-116OthersInhibitorinhibitorinhibit

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Product name:
Latanoprostene bunod
Cat. No.:
HY-19518
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