2. Search Result
Search Result
Results for "

REV-ERB Inhibitor

" in MedChemExpress (MCE) Product Catalog:
Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-14415
    SR8278
    10+ Cited Publications

    		 REV-ERB Neurological Disease Metabolic Disease
    SR8278 is a REV-ERBα antagonist and inhibits the REV-ERBα transcriptional repression activity with an EC50 of 0.47 μM. SR8278 is used to regulate the metabolism in organisms and study biological rhythm. SR8278 also can be used for the research of Duchenne muscular dystrophy and Alzheimer's disease .
    SR8278
  • HY-148711
    STL1267
    2 Publications Verification

    		 REV-ERB Metabolic Disease Inflammation/Immunology Cancer
    STL1267 is a potent and cross-the-blood-brain barrier REV-ERB agonist with a Ki value of 0.16 µM for REV-ERBα. STL1267 shows no cytotoxicity. STL1267 inhibits the gene expression of BMAL1 .
    STL1267
  • HY-176851
    GSK1362

    		REV-ERB Inflammation/Immunology
    GSK1362 is a selective inverse agonist of REV-ERB. GSK1362disrupts the interaction of REV-ERBα with repressive co-modulators (NCoR1, SMRT2, RIP140). GSK1362 exerts an inverse agonist effect by increasing the transcription of BMAL1 to relieve BMAL1 repression by endogenous REV-ERB ligands. GSK1362 suppresses LPS (HY-D1056)-induced inflammatory cytokine expression, inhibits IL-1β-induced Cxcl5 transcription in cells. GSK1362 can be used for the study of inflammatory diseases .
    GSK1362
  • HY-163136
    Autophagy/REV-ERB-IN-1

    		Autophagy REV-ERB Cancer
    Autophagy/REV-ERB-IN-1 (compound 24) is a dual inhibitor of autophagy and REV-ERB. Autophagy/REV-ERB-IN-1 has anti-tumor activity with a CC50 value of 2.3 μM on BTB-474 cells.
    Autophagy/REV-ERB-IN-1
  • HY-163136A
    Autophagy/REV-ERB-IN-1 hydrochloride

    		Autophagy REV-ERB Cancer
    Autophagy/REV-ERB-IN-1 hydrochloride (Compound 24) is a dual autophagy and REV-ERB inhibitor with anticancer activity. Autophagy/REV-ERB-IN-1 (hydrochloride) has improved potency in blocking autophagy, enhanced toxicity against cancer cells. Autophagy/REV-ERB-IN-1 (hydrochloride) can be used for the research for melanoma .
    Autophagy/REV-ERB-IN-1 hydrochloride
  • HY-156458A
    (R)-SR-29065

    		REV-ERB Inflammation/Immunology
    (R)-SR-29065 is a selective REV-ERBα inhibitor with a IC50 of 10 nM. (R)-SR-29065 is applicable to research related to autoimmune diseases .
    (R)-SR-29065

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: