Autophagy/REV-ERB-IN-1
Autophagy/REV-ERB-IN-1 (compound 24) is a dual inhibitor of autophagy and REV-ERB. Autophagy/REV-ERB-IN-1 has anti-tumor activity with a CC50 value of 2.3 μM on BTB-474 cells.
For research use only. We do not sell to patients.
- CAS No.: 3037523-29-5
- Formula: C24H30F2N2
- Molecular Weight:384.51
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A-375 | CC50 |
2.56 μM
Compound: 24
|
Cytotoxicity against human A-375 cells
Cytotoxicity against human A-375 cells
|
[PMID: 38117953] |
| BT-474 | CC50 |
2.31 μM
Compound: 24
|
Cytotoxicity against human BT-474 cells
Cytotoxicity against human BT-474 cells
|
[PMID: 38117953] |
| Capan-2 | CC50 |
6.86 μM
Compound: 24
|
Cytotoxicity against human Capan-2 cells
Cytotoxicity against human Capan-2 cells
|
[PMID: 38117953] |
| HCT-116 | CC50 |
4.56 μM
Compound: 24
|
Cytotoxicity against human HCT-116 cells
Cytotoxicity against human HCT-116 cells
|
[PMID: 38117953] |
| HepG2 | CC50 |
1.49 μM
Compound: 24
|
Cytotoxicity against human HepG2 cells
Cytotoxicity against human HepG2 cells
|
[PMID: 38117953] |
| HMEC | CC50 |
>30 μM
Compound: 24
|
Cytotoxicity against HMECs
Cytotoxicity against HMECs
|
[PMID: 38117953] |
| HT-29 | CC50 |
4.74 μM
Compound: 24
|
Cytotoxicity against human HT-29 cells
Cytotoxicity against human HT-29 cells
|
[PMID: 38117953] |
| MDA-MB-231 | CC50 |
2.97 μM
Compound: 24
|
Cytotoxicity against human MDA-MB-231 cells
Cytotoxicity against human MDA-MB-231 cells
|
[PMID: 38117953] |
Chemical Information
-
CAS No. 3037523-29-5
-
Molecular Weight 384.51
-
Formula C24H30F2N2
-
SMILES
FC1=CC=C(C2(NCC3=CC=C(F)C(CC4CCNCC4)=C3)CCCC2)C=C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)