Autophagy/REV-ERB-IN-1

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Autophagy/REV-ERB-IN-1 (compound 24) is a dual inhibitor of autophagy and REV-ERB. Autophagy/REV-ERB-IN-1 has anti-tumor activity with a CC₅₀ value of 2.3 μM on BTB-474 cells.

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Autophagy/REV-ERB-IN-1 Chemical Structure

CAS No. : 3037523-29-5

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Other Forms of Autophagy/REV-ERB-IN-1:

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Biological Activity
Purity & Documentation
References
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Description

Autophagy/REV-ERB-IN-1 (compound 24) is a dual inhibitor of autophagy and REV-ERB. Autophagy/REV-ERB-IN-1 has anti-tumor activity with a CC₅₀ value of 2.3 μM on BTB-474 cells.

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	CC₅₀	2.56 μM Compound: 24	Cytotoxicity against human A-375 cells Cytotoxicity against human A-375 cells	[PMID: 38117953]
BT-474	CC₅₀	2.31 μM Compound: 24	Cytotoxicity against human BT-474 cells Cytotoxicity against human BT-474 cells	[PMID: 38117953]
Capan-2	CC₅₀	6.86 μM Compound: 24	Cytotoxicity against human Capan-2 cells Cytotoxicity against human Capan-2 cells	[PMID: 38117953]
HCT-116	CC₅₀	4.56 μM Compound: 24	Cytotoxicity against human HCT-116 cells Cytotoxicity against human HCT-116 cells	[PMID: 38117953]
HMEC	CC₅₀	> 30 μM Compound: 24	Cytotoxicity against HMECs Cytotoxicity against HMECs	[PMID: 38117953]
HT-29	CC₅₀	4.74 μM Compound: 24	Cytotoxicity against human HT-29 cells Cytotoxicity against human HT-29 cells	[PMID: 38117953]
HepG2	CC₅₀	1.49 μM Compound: 24	Cytotoxicity against human HepG2 cells Cytotoxicity against human HepG2 cells	[PMID: 38117953]
MDA-MB-231	CC₅₀	2.97 μM Compound: 24	Cytotoxicity against human MDA-MB-231 cells Cytotoxicity against human MDA-MB-231 cells	[PMID: 38117953]

Molecular Weight

384.51

Formula

C₂₄H₃₀F₂N₂

CAS No.

3037523-29-5

SMILES

FC1=CC=C(C2(NCC3=CC=C(F)C(CC4CCNCC4)=C3)CCCC2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Martina Palomba, et al. Identification of a Dual Autophagy and REV-ERB Inhibitor with in Vivo Anticancer Efficacy. J Med Chem. 2024, 67, 1. [Content Brief]