2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. REV-ERB
  4. STL1267

STL1267 is a potent and cross-the-blood-brain barrier REV-ERB agonist with a Ki value of 0.16 µM for REV-ERBα. STL1267 shows no cytotoxicity. STL1267 inhibits the gene expression of BMAL1.

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STL1267 Chemical Structure

STL1267 Chemical Structure

CAS No. : 1429024-58-7

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Based on 1 publication(s) in Google Scholar

STL1267 Related Antibodies

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Description

STL1267 is a potent and cross-the-blood-brain barrier REV-ERB agonist with a Ki value of 0.16 µM for REV-ERBα. STL1267 shows no cytotoxicity. STL1267 inhibits the gene expression of BMAL1[1].

IC50 & Target

Ki: 0.16 µM (REV-ERBα)[1]
In Vitro

STL1267 (5 µM; 24 h) decreases the expression of BMAL1 and increases the gene expression of Mtnd1, Mtco1, Vicad, Lcad, Scad, Lkb1, Sirt1, Nampt, Ppargc1a in HepG2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

STL1267 Related Antibodies

Cell Viability Assay[1]

Cell Line: HepG2, C2C12 cells
Concentration: 0-20 µM
Incubation Time: 24 h
Result: Showed no adverse effects on cell viability up to the maximum dose examined 20 µM.

RT-PCR[1]

Cell Line: HepG2 cells
Concentration: 5 µM
Incubation Time: 24 h
Result: Decreased the gene expression of BMAL1, increased the gene expression of Mtnd1, Mtco1, Vicad, Lcad, Scad, Lkb1, Sirt1, Nampt, Ppargc1a.
In Vivo

STL1267 (50 mg/kg; i.p.; once) inhibits Bmal1 expression in mouse[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8 weeks, male C57Bl/6 J mice[1]
Dosage: 50 mg/kg
Administration: I.p.; once
Result: Showed a plasma half-life of 1.6 h, effectively suppressed BMAL1 expression in the liver at 12 h post-administration.
Molecular Weight

322.75

Formula

C17H11ClN4O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC1=NN=C2C=CC(OC3=C(C4=CC=CC=C4)C=CC=C3)=NN12
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (77.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0984 mL 15.4919 mL 30.9837 mL
5 mM 0.6197 mL 3.0984 mL 6.1967 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0984 mL 15.4919 mL 30.9837 mL 77.4593 mL
5 mM 0.6197 mL 3.0984 mL 6.1967 mL 15.4919 mL
10 mM 0.3098 mL 1.5492 mL 3.0984 mL 7.7459 mL
15 mM 0.2066 mL 1.0328 mL 2.0656 mL 5.1640 mL
20 mM 0.1549 mL 0.7746 mL 1.5492 mL 3.8730 mL
25 mM 0.1239 mL 0.6197 mL 1.2393 mL 3.0984 mL
30 mM 0.1033 mL 0.5164 mL 1.0328 mL 2.5820 mL
40 mM 0.0775 mL 0.3873 mL 0.7746 mL 1.9365 mL
50 mM 0.0620 mL 0.3098 mL 0.6197 mL 1.5492 mL
60 mM 0.0516 mL 0.2582 mL 0.5164 mL 1.2910 mL
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STL1267 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STL12671429024-58-7STL 1267STL-1267REV-ERBHepG2C2C12 cellsno cytotoxicityBMAL1cross the blood-brain barrierInhibitorinhibitorinhibit

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