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SMARCA2-IN-2

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-159607
    PRT3789

    		PROTACs SWI/SNF Complex Cancer
    PRT3789 is a selective SMARCA2 PROTAC degrader (DC50 in HeLa cell: 0.72 nM for SMARCA2, 14 nM for SMARCA4). PRT3789 forms a stable ternary complex with Von Hippel-Lindau (VHL) E3 ligase, induces polyubiquitination at SMARCA2-specific lysine residues, and drives proteasome-dependent SMARCA2 degradation. PRT3789 disrupts SWI/SNF chromatin remodeling complex integrity, induces dissociation of specific subunits, suppresses oncogenic gene expression, reduces chromatin accessibility, and upregulates antigen processing/presentation-related gene expression. PRT3789 induces synthetic lethality, inhibits proliferation and colony formation, and drives tumor growth inhibition and regression in SMARCA4-deficient contexts. PRT3789 can be used for the research of SMARCA4-mutated solid tumors, non-small cell lung cancer, endometrial cancer, colorectal cancer, bladder cancer, esophageal cancer, ovarian cancer, and gastric cancer .
    PRT3789
  • HY-162740
    SMARCA2-IN-2

    		Epigenetic Reader Domain Cancer
    SMARCA2-IN-2 (Compound I-25) is a SMARCA2 inhibitor (IC50: 101-500 μM), and can be used for cancer research .
    SMARCA2-IN-2
  • HY-161887
    SMARCA2-IN-8

    		Epigenetic Reader Domain Cancer
    SMARCA2-IN-8 (Compound 13) is an orally active inhibitor for SWI/SNF chromatin remodeling complexe SMARCA2 (also known as Brahma homologue, BRM) and SMARCA4 (also known as Brahma-related gene 1, BRG1) with IC50 of 5 and 6 nM. SMARCA2-IN-8 inhibits the proliferation of SMARCA2 mutated cancer cell SKMEL5 with AAC50 of 5 nM. SMARCA2-IN-8 downregulates the SMARCA2-dependent KRT80 gene expression with AAC50 of 10 nM. SMARCA2-IN-8 exhibits antitumor efficacy and good pharmacokinetic characteristics in mice .
    SMARCA2-IN-8
  • HY-159543
    (S,R,S)-AHPC-CO-Ph-Ph-CHO

    		E3 Ligase Ligand-Linker Conjugates Cancer
    SMARCA2-ligand-Linker Conjugate-1 is an E3 ligase ligand-linker conjugate.
    (S,R,S)-AHPC-CO-Ph-Ph-CHO
  • HY-161889
    DCSM06-05

    		Epigenetic Reader Domain Cancer
    DCSM06-05 is a potent SMARCA2-BRD inhibitor with an IC50 value of 9 µM, a Kd value of 22.4 µM .
    DCSM06-05
  • HY-168230
    SMARCA2 ligand-9

    		Ligands for Target Protein for PROTAC SWI/SNF Complex Cancer
    SMARCA2 ligand-9 is the ligand of SMARCA2. SMARCA2 ligand-9 can be used to synthesize PROTAC SMARCA2 degrader-27 (HY-168229) .
    SMARCA2 ligand-9
  • HY-163865
    PROTAC SMARCA2 degrader-13

    		PROTACs Cancer
    SMARCA2 degrader-2 (compound I-322) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 <100 nM, and a maximum degradation rate (Dmax%) >90 after 24 h of treatment .
    PROTAC SMARCA2 degrader-13
  • HY-181910
    SMARCA2 ligand-19

    		Ligands for Target Protein for PROTAC SWI/SNF Complex Cancer
    SMARCA2 ligand-19 (Compound 26a) is a ligand for the target protein for PROTAC (SMARCA2). SMARCA2 ligand-19 can be used to synthesize PROTACs, such as SMARCA2 degrader-36 (HY-181909) .
    SMARCA2 ligand-19

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