PROTAC SMARCA2 degrader-13
PROTAC SMARCA2 degrader-13 is a PROTAC degrader targeting SMARCA2 and SMARCA4. PROTAC SMARCA2 degrader-13 induces ubiquitination of SMARCA2 and SMARCA4 and mediates their degradation via the proteasome. PROTAC SMARCA2 degrader-13 can be used in cancer-related research.
(Pink: SMARCA2 and SMARCA4 ligand (HY-159542); Blue: Cereblon ligand (HY-10984); Black: linker).
For research use only. We do not sell to patients.
- CAS No.: 2568276-72-0
- Formula: C37H39N9O5
- Molecular Weight:689.76
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
SMARCA2 |
SMARCA4 |
PROTAC SMARCA2 degrader-13 (I-322) (24 h) potently degrades SMARCA2 protein in A549 cells, with a DC50 value < 100 nM and a degradation rate of over 90% after 24 hours[1].
PROTAC SMARCA2 degrader-13 (24 h) potently degrades SMARCA4 protein in MV4-11 cells, with a DC50 of less than 100 nM and a degradation rate of over 90% after 24 h[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2568276-72-0
-
Molecular Weight 689.76
-
Formula C37H39N9O5
-
SMILES
O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NC4CCC(CC4)N5CCC(CC5)N6N=CC(C7=C(N)N=NC(C8=C(O)C=CC=C8)=C7)=C6)=CC=C3)=O)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC SMARCA2 degrader-13 Related Classifications
HY-163865 Related Classifications
Powered by Bioz