2. PROTAC Cell Cycle/DNA Damage
  3. Ligands for Target Protein for PROTAC SWI/SNF Complex
  4. SMARCA2 ligand-19

SMARCA2 ligand-19 (Compound 26a) is a ligand for the target protein for PROTAC (SMARCA2). SMARCA2 ligand-19 can be used to synthesize PROTACs, such as SMARCA2 degrader-36 (HY-181909).

For research use only. We do not sell to patients.

SMARCA2 ligand-19

SMARCA2 ligand-19 Chemical Structure

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SMARCA2 ligand-19 Related Antibodies

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Description

SMARCA2 ligand-19 (Compound 26a) is a ligand for the target protein for PROTAC (SMARCA2). SMARCA2 ligand-19 can be used to synthesize PROTACs, such as SMARCA2 degrader-36 (HY-181909)[1].

IC50 & Target[1]

SMARCA2

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SMARCA2 ligand-19 Related Antibodies
Molecular Weight

295.34

Formula

C17H17N3O2
SMILES

OC1=CC=CC=C1C2=NN=C3C(OC(C4CCNCC4)=C3)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SMARCA2 ligand-19 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMARCA2 ligand-19Ligands for Target Protein for PROTACSWI/SNF ComplexTarget Protein-binding MoietySWI/SNF Family of Chromatin-Remodelling ComplexesGST-tagged SMARCA2 bromodomainhumansmarca4-deficient cancerSMARCA2 bromodomainInhibitorinhibitorinhibit

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HY-181910
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