country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-181909

Copy Link Print Information

PROTAC SMARCA2 degrader-36

PROTAC SMARCA2 degrader-36 (Compound 26) is a selective and potent SMARCA2 PROTAC degrader with a DC₅₀ of 51 nM. PROTAC SMARCA2 degrader-36 promotes ubiquitination and degradation of SMARCA2. PROTAC SMARCA2 degrader-36 exhibits anticancer activity against non-small cell lung cancer. PROTAC SMARCA2 degrader-36 can be used in studies related to SMARCA4-deficient cancers.
(Pink: SMARCA2 ligand (HY-181910); Blue: VHL ligand (HY-112078); Black: linker).

For research use only. We do not sell to patients.

Formula: C₄₂H₄₉N₇O₆S
Molecular Weight:779.95

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC SMARCA2 degrader-36 Chemical Structure

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Parmacokinetics
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PROTAC SMARCA2 degrader-36 (Compound 26) is a selective and potent SMARCA2 PROTAC degrader with a DC₅₀ of 51 nM. PROTAC SMARCA2 degrader-36 promotes ubiquitination and degradation of SMARCA2. PROTAC SMARCA2 degrader-36 exhibits anticancer activity against non-small cell lung cancer. PROTAC SMARCA2 degrader-36 can be used in studies related to SMARCA4-deficient cancers^[1]. (Pink: SMARCA2 ligand (HY-181910); Blue: VHL ligand (HY-112078); Black: linker).

IC₅₀ & Target^[1]

VHL

SMARCA2

All PROTACs Isoforms :

All SWI/SNF Complex Isoforms :

Parmacokinetics

Species	Dose	Route	T_1/2	C_max	AUC_0-t	CL	Bioavailability
Mice^[1]	1 mg/kg	i.v.	0.632 h	578 ng/mL	304	3323 mL/h/kg	/
Mice^[1]	3 mg/kg	p.o.	0.963 h	8.29 ng/mL	4.38	/	0.592 %

In Vivo

PROTAC SMARCA2 degrader-36 (50-100 mg/kg; i.v.; three times per week for 21 days) significantly inhibits the growth of SMARCA4-deficient NCI-H1944 xenograft tumors in BALB/c nude mice^[1].
Compound 26 (100 mg/kg; i.v.; single dose) induces sustained SMARCA2 degradation for up to 24 hours in NCI-H1944 xenograft tumors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c nude SCID (female)^[1]
Dosage:

100 mg/kg
Administration:

i.v.; three times per week for 21 days or single
Result:

Achieved a tumor/control (T/C) ratio of 48.9% at 100 mg/kg.
Achieved a tumor/control (T/C) ratio of 63.9% at 50 mg/kg.
Showed no significant body weight loss.
Confirmed degradation of target protein SMARCA2.

Chemical Information

Molecular Weight 779.95
Formula C₄₂H₄₉N₇O₆S
SMILES

O=C([C@H]1N(C([C@@H](NC(CN2CCC(C3=CC4=NN=C(C5=CC=CC=C5O)C=C4O3)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Diao J, et al. Design, synthesis and pharmacological evaluation of new SMARCA2 degraders bearing a furo[3,2-c]pyridazine scaffold. Eur J Med Chem. 2026;308:118675. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

Get Quote In-stock

Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

PROTAC SMARCA2 degrader-36

All PROTACs Isoforms

All SWI/SNF Complex Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC SMARCA2 degrader-36 Related Classifications

HY-181909 Related Classifications