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TAO

" in MedChemExpress (MCE) Product Catalog:

By Targets:	IGF-1R (1) MAP3K (1) Ser/Thr Protease (2) TSH Receptor (1)
By Research Areas:	Cancer (3) Endocrinology (1)

5

Inhibitors & Agonists

1

Inhibitory Antibodies

4

Recombinant Proteins

1

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

TAO Kinase inhibitor 2	Ser/Thr Protease	Cancer
TAO Kinase inhibitor 2 (Example 49) is a TAO Kinase inhibitor (IC₅₀=between 50 and 500 nM). TAO Kinase inhibitor 2 also inhibits KIAA1361 and JIK with IC₅₀s of 50-500 nM .

TAO Kinase inhibitor 1 1 Publications Verification CP 43	MAP3K	Cancer
TAO Kinase inhibitor 1 (compound 43) is a selective, ATP-competitive thousand-and-one amino acid kinases (TAOK) inhibitor with IC₅₀s of 11 to 15 nM for TAOK1 and 2, respectively. TAO Kinase inhibitor 1 delays mitosis and induces mitotic cell death .

Teprotumumab	IGF-1R TSH Receptor	Endocrinology
Teprotumumab is an IGF-1 receptor (IGF-1R) blocking human monoclonal antibody. Teprotumumab binds to the ligand binding extracellular α-subunit domain of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab attenuates TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used for thyroid-associated ophthalmopathy research .

SBI-581	Ser/Thr Protease	Cancer
SBI-581 is an orally active and potent selective serine-threonine kinase *TAO3* inhibitor, with an IC₅₀ of 42 nM. SBI-581 promotes TKS5α accumulation at RAB11-positive vesicles. SBI-581 inhibits invadopodia formation. SBI-581 shows reasonable pharmacokinetics in mice using IP injection. SBI-581 shows antitumor activity . SBI-581 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-124059

SW-034538

Others Others

SW-034538 is a TAO2 inhibitor, with an IC₅₀ of 300 nM .

Species:	Human (4)
Tag:	His (2) Tag Free (1) GST (3)
Source:	Sf9 insect cells (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P702749

TAOK1 Protein, Human (sf9, His, GST)

TAOK1; TAO kinase 1; DDIB; PSK2; TAO1; KFC-B; MARKK; PSK-2; hKFC-B; hTAOK1; MAP3K16
Human Sf9 insect cells

	TAOK3 Protein, Human (sf9, His-GST) Serine/threonine-protein kinase TAO3; JNK/SAPK-inhibitory kinase; DPK; JIK; KDS; MAP3K18	Human	Sf9 insect cells
	TAOK3, a kinase, regulates the p38/MAPK14 and MAPK8/JNK cascades. It activates the p38/MAPK14 cascade, particularly in DNA damage-induced G2/M transition, likely through MAP2K3 and MAP2K6 phosphorylation. TAOK3 inhibits basal MAPK8/JNK activity and dampens its response to epidermal growth factor. These functions showcase TAOK3's role in coordinating cellular responses to DNA damage and growth factor signaling. TAOK3 Protein, Human (sf9, His-GST) is the recombinant human-derived TAOK3 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of TAOK3 Protein, Human (sf9, His-GST) is 411 a.a., with molecular weight of ~85 kDa.

	TAOK2 Protein, Human (Sf9, GST) TAOK2; Serine/threonine-protein kinase TAO2; Kinase from chicken homolog C; hKFC-C; Prostate-derived sterile 20-like kinase 1; PSK-1; PSK1; Prostate-derived STE20-like kinase 1; Thousand and one amino acid protein kinase 2	Human	Sf9 insect cells
	TAOK2 is a multifunctional serine/threonine protein kinase that affects membrane blebbing, apoptotic body formation, DNA damage response, and the MAPK14/p38 MAPK cascade. It exhibits broad substrate specificity and can phosphorylate itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulin. TAOK2 Protein, Human (Sf9, GST) is the recombinant human-derived TAOK2 protein, expressed by Sf9 insect cells , with N-GST labeled tag. The total length of TAOK2 Protein, Human (Sf9, GST) is 314 a.a., .

	TAOK2 Protein, Human (Sf9) TAOK2; Serine/threonine-protein kinase TAO2; Kinase from chicken homolog C; hKFC-C; Prostate-derived sterile 20-like kinase 1; PSK-1; PSK1; Prostate-derived STE20-like kinase 1; Thousand and one amino acid protein kinase 2	Human	Sf9 insect cells
	TAOK2 is a multifunctional serine/threonine protein kinase that affects membrane blebbing, apoptotic body formation, DNA damage response, and the MAPK14/p38 MAPK cascade. It exhibits broad substrate specificity and can phosphorylate itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulin. TAOK2 Protein, Human (Sf9) is the recombinant human-derived TAOK2 protein, expressed by Sf9 insect cells , with tag free. The total length of TAOK2 Protein, Human (Sf9) is 314 a.a., .

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