TAOK1 Protein, Human (Active, sf9, His, GST)
TAOK1 Protein, Human (sf9, His, GST) is the recombinant human-derived TAOK1, expressed by Sf9 insect cells , with His, GST labeled tag. ,
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
TAOK1 Protein, Human (sf9, His, GST) is the recombinant human-derived TAOK1, expressed by Sf9 insect cells , with His, GST labeled tag. ,
Background
TAOK1 is a serine/threonine-protein kinase involved in multiple biological processes, including the p38/MAPK14 stress-activated MAPK cascade, DNA damage response, and cytoskeleton stability regulation. It activates the p38/MAPK14 cascade by phosphorylating MAP2K3 and MAP2K6, thereby participating in the G2/M checkpoint response to DNA damage. Additionally, TAOK1 phosphorylates Thr-208 of MARK2 to activate its kinase activity, leading to the detachment of MAPT/TAU from microtubules and maintaining cytoskeletal stability. This kinase also regulates apoptotic morphological changes (e.g., cell contraction, membrane blebbing) via the MAPK8/JNK cascade. TAOK1 plays an essential role in neuronal development within the central nervous system (PubMed:33565190) and is implicated in neuronal migration to the cortical plate (by similarity).
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag His;GST
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Accession
Q7L7X3-1 (P2-K314)
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Gene ID57551
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Protein Length
Partial
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Synonyms
TAOK1; Serine/Threonine-Protein Kinase TAO1; TAO Kinase 1; Prostate-Derived STE20-Like Kinase 2; MAP3K16; Kinase From Chicken Homolog B; HTAOK1; FLJ14314; HKFC-B; PSK-2; MARKK; Microtubule Affinity Regulating Kinase Kinase; PSK2; Serine/Threonine Protein
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AA Sequence
PSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKK
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Purity
≥ 80%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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