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TBK1+inhibitor

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-111941
    GSK8612
    25+ Cited Publications

    		 IKK Neurological Disease Inflammation/Immunology Cancer
    GSK8612 is a highly selective and potent Tank-binding Kinase-1 (TBK1) inhibitor, with a pIC50 of 6.8 for recombinant TBK1 [1].
    GSK8612
  • HY-152237
    TBK1-IN-1

    		IKK Cancer
    TBK1-IN-1 is a potent and selective TANK binding kinase 1 (TBK1) inhibitor with an IC50 value of 22.4 nM. TBK1-IN-1 inhibits TBK1 downstream target genes cxcl10 and ifnβ expression. TBK1-IN-1 has anticancer activity [1].
    TBK1-IN-1
  • HY-176334
    TBK1 ligand 2

    		Ligands for Target Protein for PROTAC IKK Cancer
    TBK1 ligand 2 (Compound 1b) is a TBK1 inhibitor. TBK1 ligand 2 can be used for synthesis of PROTAC TBK1 degrader-2 (HY-112557) [1].
    TBK1 ligand 2
  • HY-110341
    MRT 68601 hydrochloride

    		IKK Cancer
    MRT 68601 hydrochloride is a TBK1 inhibitor with an IC50 value of 6 nM. MRT 68601 hydrochloride inhibits autophagosome formation in lung cancer cells [1] .
    MRT 68601 hydrochloride
  • HY-133117A
    (Rac)-BAY-985

    		IKK Cancer
    (Rac)-BAY-985 (Compound Example 100.01) is a potent, ATP-competitive and selective TBK1 inhibitor with an IC50 of 1.5 nM. Antitumor efficacy [1].
    (Rac)-BAY-985
  • HY-178915
    ITA-5

    		IKK IFNAR STAT Inflammation/Immunology
    ITA-5 is a TBK1 inhibitor based on the structure of itaconic acid. can significantly inhibit the secretion of IFN-β. ITA-5 can inhibit the phosphorylation of TBK1, IRF3, and STAT1. ITA-5 can be used for research on autoimmune diseases and excessive inflammation [1].
    ITA-5
  • HY-178916
    ITA-9

    		IKK IFNAR STAT Inflammation/Immunology
    ITA-9 is a TBK1 inhibitor based on the structure of itaconic acid. ITA-9 can inhibit the IFN-I signaling pathway. ITA-9 can inhibit the phosphorylation of TBK1, IRF3, and STAT1. ITA-9 can be used for research on inflammatory reactions and tissue damage [1].
    ITA-9
  • HY-173462
    TBK1-IN-2

    		IKK Cancer
    TBK1-IN-2 (Compound A1) is a potent TBK1 inhibitor (IC50: 775 pM). TBK1-IN-2 binds to TBK1 through stable hydrogen bonds and π-π stacking, inhibiting IRF3 phosphorylation. TBK1-IN-2 synergizes with TNF/IFNγ to enhance immune-mediated tumor cell death. TBK1-IN-2 can be used in cancer immunotherapy research [1].
    TBK1-IN-2
  • HY-172620
    LIB3S0280

    		IKK Akt Apoptosis PI3K NF-κB CDK Caspase PARP Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    LIB3S0280 is a potent TBK1 inhibitor with an IC50 value of 493.9 nM. LIB3S0280 exhibits better anticancer effects in pancreatic cancer cell lines with high TBK1 expression. LIB3S0280 inhibits TBK1 downstream signaling pathways, including PI3K/AKT and NF-κB. LIB3S0280 induces G2/M arrest, apoptosis and cellular senescence. LIB3S0280 can be used for pancreatic ductal adenocarcinoma (PDAC) research [1].
    LIB3S0280
  • HY-148206
    DMX-129

    		IKK Cancer
    DMX-129 is an ΙΚΚε and TBK-1 inhibitor with IC50 values of <30 nM for both TBK1 and IKKε [1].
    DMX-129
  • HY-118326
    MRT 68601

    		Autophagy Cancer
    MRT 68601 is a potent TBK1 inhibitor with the activity of inhibiting autophagosome formation in lung cancer cells. MRT 68601 may have potential effects against targets associated with host-dependent factors identified in SARS-CoV-2 infection. The drug targets involved in MRT 68601 are related to existing FDA-approved drugs and compounds in clinical trials, which can provide support for the development of broad-spectrum antiviral therapies [1].
    MRT 68601

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