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Cat. No.: HY-148206

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DMX-129

DMX-129 is an ΙΚΚε and TBK-1 inhibitor with IC₅₀ values of <30 nM for both TBK1 and IKKε.

For research use only. We do not sell to patients.

CAS No.: 1623123-95-4
Formula: C₁₉H₁₇FN₈
Molecular Weight:376.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

DMX-129 Chemical Structure

CAS No.: 1623123-95-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

DMX-129 is an ΙΚΚε and TBK-1 inhibitor with IC₅₀ values of <30 nM for both TBK1 and IKKε^[1].

IC₅₀ & Target

IC₅₀: <30 nM (TBK-1), <30 nM (ΙΚΚε)^[1]

All IKK Isoforms :

Chemical Information

CAS No. 1623123-95-4
Molecular Weight 376.39
Formula C₁₉H₁₇FN₈
SMILES

N#CC1=C(N2CC[C@@H](C2)F)N=CC(C3=NC(NC4=CN=C(N)C=C4)=NC=C3)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gary Karl Newton, et al. Pyrimidine compounds useful in the treatment of diseases mediated by ikke and/or tbk1 mechanisms. Patent WO2014128486A1.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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DMX-129

All IKK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

DMX-129 Related Classifications

HY-148206 Related Classifications