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Results for "

TGFα

" in MedChemExpress (MCE) Product Catalog:

6

Inhibitors & Agonists

1

Screening Libraries

1

Peptides

1

Inhibitory Antibodies

1

Natural
Products

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P990071
    Fepixnebart

    LY-3016859

    		 EGFR Neurological Disease Metabolic Disease Inflammation/Immunology
    Fepixnebart (LY3016859) is a humanized monoclonal hIgG4 antibody, which binds and neutralizes only TGFα and epiregulin with high affinity. Fepixnebart can be used for the study of diabetic nephropathy and broad-spectrum chronic pain, including diabetic peripheral neuropathic pain (DPNP), signs and symptoms of osteoarthritis (OA), and chronic low back pain (CLBP) .
    Fepixnebart
  • HY-N16121
    12-Deoxyphorbol 13-isobutyrate

    		PKC Neurological Disease
    12-Deoxyphorbol 13-isobutyrate (ER272) (DPB), a diterpene, is a PKCα activator. 12-Deoxyphorbol 13-isobutyrate can be isolated from Euphorbia resinifera's latex. 12-Deoxyphorbol 13-isobutyrate facilitates neural stem cells (NSCs) proliferation and activation as well as TGFα release in a reaction dependent on PKCα activation. 12-Deoxyphorbol 13-isobutyrate increases cognitive performance and hippocampal neurogenesis in senescence-accelerated mouse-prone (SAMP8) models. 12-Deoxyphorbol 13-isobutyrate can be used for neurodegenerative diseases research .
    12-Deoxyphorbol 13-isobutyrate
  • HY-P4976
    TGF α (1-50) (rat)

    		Biochemical Assay Reagents Inflammation/Immunology
    TGF α (1-50) (rat) TGF alpha (1-50) (rat) is an anti-inflammatory peptide useful in the study of inflammation and immunity .
    TGF α (1-50) (rat)
  • HY-174779
    Human AREG mRNA

    		mRNA Cancer
    Human AREG mRNA encodes the human amphiregulin (AREG) protein, a member of the epidermal growth factor family. AREG interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development.
    Human AREG mRNA
  • HY-165060
    (±)2-(14,15-Epoxyeicosatrienoyl) glycerol

    (±)2-14,15-EG

    		 DNA/RNA Synthesis Metabolic Disease
    (±)2-(14,15-Epoxyeicosatrienoyl) glycerol ((±)2-14,15-EG) is a novel CYP450 metabolite of 2-Arachidonoyl glycerol (2-AG) in the kidney. (±)2-(14,15-Epoxyeicosatrienoyl) glycerol is a potent mitogen for renal epithelial cells, increasing DNA synthesis in LLCPKcl4 cells. (±)2-(14,15-Epoxyeicosatrienoyl) glycerol activates the metalloprotease ADAM17, which cleaves proTGF-α and releases TGF-α as a ligand that initiates the EGFR-ERK signalling pathway .
    (±)2-(14,15-Epoxyeicosatrienoyl) glycerol
  • HY-20888
    3'-Methoxy-4'-nitroflavone

    MNF

    		 Aryl Hydrocarbon Receptor Cytochrome P450 Apoptosis Akt ERK TGF-beta/Smad Neurological Disease Inflammation/Immunology Cancer
    3'-Methoxy-4'-nitroflavone (MNF) is a specific aryl hydrocarbon receptor (AhR) antagonist. 3'-Methoxy-4'-nitroflavone activates AhR by inhibiting CYP1, the metabolic enzyme of the endogenous ligand FICZ (HY-12451), leading to the accumulation of FICZ. 3'-Methoxy-4'-nitroflavone reverses the anti-apoptotic effect of TCDD, attenuates the activation of Akt and Erk1/2 kinases and the expression of TGFα induced by TCDD. 3'-Methoxy-4'-nitroflavone can be used in research related to breast tumor promotion, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease .
    3'-Methoxy-4'-nitroflavone

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