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Topoisomerase IIα/EGFR-TK inhibitors

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-180823
    Topoisomerase II/EGFR-IN-2

    		Topoisomerase EGFR Apoptosis Caspase Bcl-2 Family Cancer
    Topoisomerase II/EGFR-IN-2 (Compound 3) is an inhibitor of Topoisomerase IIα (IC50 = 0.122 μM) and EGFR-TK WT (IC50 = 16.8 μM). Topoisomerase II/EGFR-IN-2 inhibits the proliferation of HeLa and HepG2 cells, inducing cell cycle arrest and apoptosis. Topoisomerase II/EGFR-IN-2 upregulates caspase-3 and Bax, and downregulates Bcl-2. Topoisomerase II/EGFR-IN-2 can be used to study liver cancer and cervical cancer .
    Topoisomerase II/EGFR-IN-2

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