Topoisomerase II/EGFR-IN-2
Topoisomerase II/EGFR-IN-2 (Compound 3) is an inhibitor of Topoisomerase IIα (IC50 = 0.122 μM) and EGFR-TKWT (IC50 = 16.8 μM). Topoisomerase II/EGFR-IN-2 inhibits the proliferation of HeLa and HepG2 cells, inducing cell cycle arrest and apoptosis. Topoisomerase II/EGFR-IN-2 upregulates caspase-3 and Bax, and downregulates Bcl-2. Topoisomerase II/EGFR-IN-2 can be used to study liver cancer and cervical cancer.
For research use only. We do not sell to patients.
- Formula: C6H7N7O2S
- Molecular Weight:241.23
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
topoisomerase II alpha 0.122 μM (IC50) |
EGFRWT 16.8 μM (IC50) |
Bax |
Caspase 3 |
Bcl-2 |
Chemical Information
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Molecular Weight 241.23
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Formula C6H7N7O2S
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SMILES
O=C(C1=CC(N=C2N1N=C(NN)S2)=O)NN
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Topoisomerase II/EGFR-IN-2 Related Classifications
HY-180823 Related Classifications
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