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ZBP1 PROTAC-1

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-177119
    ZBP1 Covalent PROTAC-1

    		PROTACs RIP kinase Mixed Lineage Kinase Infection Inflammation/Immunology
    ZBP1 Covalent PROTAC-1 is a covalent Z-DNA binding protein 1 ZBP1 PROTAC degrader, with its DC50 being 25.69 nM. ZBP1 Covalent PROTAC-1 integrates the ligand that recruits the VHL E3 ubiquitin ligase and the DNA aptamer (Aptamer Z3) with the specific Zα domain that can bind to ZBP1, which has a high affinity (KD = 2.71 nM) with ZBP1. After degrading ZBP1, the phosphorylation levels of downstream signaling molecules RIPK3 and MLKL significantly decrease. ZBP1 Covalent PROTAC-1, encapsulated by nano-liposomes, significantly improves the survival rate of mice infected with influenza A virus (IAV) after administration via the trachea [1].
    ZBP1 Covalent PROTAC-1
  • HY-185102
    ZBP1 PROTAC-1

    		PROTACs Cancer
    ZBP1 PROTAC-1 (2a+aptamer) is a Z-DNA binding protein 1 (ZBP1) PROTAC. ZBP1 PROTAC-1 consists of a DNA aptamer (specifically binds to ZBP1) and an E3 enzyme-recruiting unit. ZBP1 PROTAC-1 combines the high specificity of DNA aptamers with the degradation-inducing capabilities of PROTACs, providing a powerful tool for targeted protein degradation [1].
    ZBP1 PROTAC-1

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