ZBP1 Covalent PROTAC-1 

ZBP1 Covalent PROTAC-1 is a covalent Z-DNA binding protein 1 ZBP1 PROTAC degrader, with its DC₅₀ being 25.69 nM. ZBP1 Covalent PROTAC-1 integrates the ligand that recruits the VHL E3 ubiquitin ligase and the DNA aptamer (Aptamer Z3) with the specific Zα domain that can bind to ZBP1, which has a high affinity (K_D = 2.71 nM) with ZBP1. After degrading ZBP1, the phosphorylation levels of downstream signaling molecules RIPK3 and MLKL significantly decrease. ZBP1 Covalent PROTAC-1, encapsulated by nano-liposomes, significantly improves the survival rate of mice infected with influenza A virus (IAV) after administration via the trachea^[1].

24590.00

Solid

White to pink

O=C(CCCCC(N(CC#N)S(=O)(C1=CC=C(C=C1)CCS[3'-AAGTGCCATCGTGCGTATCCCTCGCGTCTGCTTGCTC GTCCCAACCCACCACCGCCCGATACGCACCTCACGACTT-5'])=O)=O)N2C3=C(C4=C(C5=C(C2)C=CC=C5)N(CCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N6C[C@@H](C[C@H]6C(NCC7=CC=C(C8=C(C)N=CS8)C=C7)=O)O)=O)=O)N=N4)C=CC=C3

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Huang R, et al. Targeted Degradation of ZBP1 with Covalent PROTACs for Anti-Inflammatory Treatment of Infections. Angew Chem Int Ed Engl. 2025 May;64(19):e202423524.  [Content Brief]