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alpha+globin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Isotope-Labeled Compounds (1) Platelet-activating Factor Receptor (PAFR) (3) Reference Standards (1) TGF-beta/Smad (1)
By Research Areas:	Inflammation/Immunology (3) Metabolic Disease (1)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108634

Apafant 3 Publications Verification WEB 2086	Platelet-activating Factor Receptor (PAFR)	Inflammation/Immunology
Apafant (WEB 2086), a chemical probe, is a potent platelet-activating factor (PAF) antagonist, inhibits PAF binding to human PAF receptors with a K_i of 9.9 nM. Apafant increases the gene expression of PAF-r, α-globin, β-globin, decreases the c-myb gene expression. Apafant shows a protective effect on alkyl-PAF-mediated lethalit .

HY-P99720A

Luspatercept (mIgG2a) RAP-536	TGF-beta/Smad	Metabolic Disease
Luspatercept (mIgG2a) (RAP-536) is a fusion protein, consisting of a modified extracellular domain of human ActRIIB linked to the murine IgG2a Fc domain. Luspatercept (mIgG2a) inhibits Smad2/3 signaling, promotes differentiation of late-stage erythroid precursors and mitigates ineffective erythropoiesis (IE) in murine β-thalassemia. Luspatercept (mIgG2a) reduces anemia, α-globin aggregates, hemolysis, and disease complications of IE such as iron overload, splenomegaly, and bone defects .

HY-108634S

Apafant-d8 WEB 2086-d₈	Isotope-Labeled Compounds Platelet-activating Factor Receptor (PAFR)	Inflammation/Immunology
Apafant-d₈ is the deuterium labeled Apafant. Apafant (WEB 2086) is a potent platelet-activating factor (PAF) antagonist, inhibits PAF binding to human PAF receptors with a K_iof 9.9 nM. Apafant increases the gene expression of PAF-r, α-globin, β-globin, decreases the c-myb gene expression. Apafant shows a protective effect on alkyl-PAF-mediated lethalit .

HY-108634R

Apafant (Standard) WEB 2086 (Standard)	Reference Standards Platelet-activating Factor Receptor (PAFR)	Inflammation/Immunology
Apafant (Standard) is the analytical standard of Apafant (HY-108634). This product is intended for research and analytical applications. Apafant (WEB 2086), a chemical probe, is a potent platelet-activating factor (PAF) antagonist, inhibits PAF binding to human PAF receptors with a K_i of 9.9 nM. Apafant increases the gene expression of PAF-r, α-globin, β-globin, decreases the c-myb gene expression. Apafant shows a protective effect on alkyl-PAF-mediated lethalit .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99720A

Luspatercept (mIgG2a) RAP-536	TGF-beta/Smad	Metabolic Disease
Luspatercept (mIgG2a) (RAP-536) is a fusion protein, consisting of a modified extracellular domain of human ActRIIB linked to the murine IgG2a Fc domain. Luspatercept (mIgG2a) inhibits Smad2/3 signaling, promotes differentiation of late-stage erythroid precursors and mitigates ineffective erythropoiesis (IE) in murine β-thalassemia. Luspatercept (mIgG2a) reduces anemia, α-globin aggregates, hemolysis, and disease complications of IE such as iron overload, splenomegaly, and bone defects .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P70397

	*Hemoglobin subunit alpha/HBA1 Protein, Human (His)* rHuHemoglobin subunit alpha/HBA1, His; Hemoglobin subunit alpha; Alpha-globin; Hemoglobin alpha chain; HBA1; HBH; HBA-T3	Human	E. coli
	Hemoglobin subunit alpha/HBA1 protein plays a crucial role in oxygen transport and gas exchange within the human body. It also acts as a regulator in the cannabinoid receptor pathway by interacting with hemopressin, a CNR1 antagonist. This dual functionality highlights the multifaceted significance of HBA1, contributing not only to vital oxygen transport but also to the modulation of cannabinoid receptor-mediated processes. Hemoglobin subunit alpha/HBA1 Protein, Human (His) is the recombinant human-derived Hemoglobin subunit alpha/HBA1 protein, expressed by E. coli , with N-6*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-108634S

Apafant-d8
Apafant-d₈ is the deuterium labeled Apafant. Apafant (WEB 2086) is a potent platelet-activating factor (PAF) antagonist, inhibits PAF binding to human PAF receptors with a K_iof 9.9 nM. Apafant increases the gene expression of PAF-r, α-globin, β-globin, decreases the c-myb gene expression. Apafant shows a protective effect on alkyl-PAF-mediated lethalit .

Host:	Rabbit (2)
Reactivity:	Human (2)
Application:	IHC-P (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81428

	*Hemoglobin subunit alpha* Antibody (YA1173)** HBA1; HBA2; Hemoglobin subunit alpha; Alpha-globin; Hemoglobin alpha chain; Hemopressin	IHC-P	Human
	Hemoglobin subunit alpha Antibody (YA1173) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Hemoglobin subunit alpha.

HY-P81428A

	*Hemoglobin subunit alpha* Antibody (YA1173)(PBS only)** HBA1; HBA2; Hemoglobin subunit alpha; Alpha-globin; Hemoglobin alpha chain; Hemopressin	IHC-P	Human
	Hemoglobin subunit alpha Antibody (YA1173) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Hemoglobin subunit alpha.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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