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anti-M1 muscarinic activity

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. 상품명 Target 연구분야 Chemical Structure
  • HY-B1277
    Trihexyphenidyl hydrochloride
    3 Publications Verification

    		 mAChR Cholinesterase (ChE) Neurological Disease
    Trihexyphenidyl hydrochloride is a selective and orally active M1 muscarinic receptor antagonist with an IC50 of 3.7 nM for rat cerebral cortex M1 muscarinic receptors. Trihexyphenidyl hydrochloride modulates cholinergic activity, countering acetylcholine supersensitivity in neural pathways. Trihexyphenidyl hydrochloride improves movement disorder, inhibits McN-A-343 (HY-107648)-induced pressor responses, vagally-induced bradycardia and vasodilatation. Trihexyphenidyl hydrochloride can be used for the research of Parkinson's disease. .
    Trihexyphenidyl hydrochloride
  • HY-B1277R
    Trihexyphenidyl hydrochloride (Standard)

    		Reference Standards mAChR Cholinesterase (ChE) Neurological Disease
    Trihexyphenidyl hydrochloride (Standard) is the analytical standard of Trihexyphenidyl hydrochloride (HY-B1277). This product is intended for research and analytical applications. Trihexyphenidyl is a selective and orally active M1 muscarinic receptor antagonist with an IC50 of 3.7 nM for rat cerebral cortex M1 muscarinic receptors. Trihexyphenidyl modulates cholinergic activity, countering acetylcholine supersensitivity in neural pathways. Trihexyphenidyl improves movement disorder, inhibits McN-A-343 (HY-107648)-induced pressor responses, vagally-induced bradycardia and vasodilatation. Trihexyphenidyl can be used for the research of Parkinson's disease. .
    Trihexyphenidyl hydrochloride (Standard)

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