bioconjugates

By Targets:	Cholecystokinin Receptor (1) DNA Stain (1) Dopamine Receptor (1) Fluorescent Dye (3) PROTACs (1) Ras (1)
By Research Areas:	Cancer (2) Infection (1) Inflammation/Immunology (1) Neurological Disease (1)
Click Chemistry:	Tetrazine (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-134566

NBD-X, SE

Fluorescent Dye Others

NBD-X, SE, the acceptor fluorophore, can be used to create environment sensitive bioconjugates .
HY-135140A

Methyltetrazine-amine hydrochloride

Others Others

Methyltetrazine-Amine, a tetrazine compound, is used for the site-specific dual functionalization of the resulting bioconjugates .

NBD-X, SE	Fluorescent Dye	Others
NBD-X, SE, the acceptor fluorophore, can be used to create environment sensitive bioconjugates .

Methyltetrazine-amine hydrochloride	Others	Others
Methyltetrazine-Amine, a tetrazine compound, is used for the site-specific dual functionalization of the resulting bioconjugates .

HY-15943

6-TAMRA 1 Publications Verification 6-Carboxytetramethylrhodamine	DNA Stain	Others
6-TAMRA has been a widely used fluorophore for preparing bioconjugates, especially fluorescent antibody and avidin derivatives used in immunochemistry.

HY-149744

FXb

Others Inflammation/Immunology

FXb is an immunizing and functionalized hapten and can be used for protein bioconjugates preparation .

FXb	Others	Inflammation/Immunology
FXb is an immunizing and functionalized hapten and can be used for protein bioconjugates preparation .

HY-W040291

7-Hydroxy-4-methylcoumarin-3-acetic acid, SE	Fluorescent Dye	Cancer
7-Hydroxy-4-methylcoumarin-3-acetic acid, SE is a blue fluorophore that has pH-dependent and environment-sensitive fluorescence. It is widely used for preparing bioconjugates of blue fluorescence.

HY-155466

Boc-MIF-1-Am	Dopamine Receptor	Neurological Disease
Boc-MIF-1-Am (compound 2) is a human dopamine D2 receptor enhancer (EC₅₀=17.82 nM) and is a bioconjugate of melanostatin (MIF-1) and amantadine. Boc-MIF-1-Am (200 μM) exhibited mild neurotoxicity in SH-SY5Y cells .

HY-160045

AP1153 aptamer sodium	Cholecystokinin Receptor	Cancer
AP1153 aptamer sodium is a DNA aptamer that specifically binds to the cholecystokinin receptor CCKBR (Kd: ~15 pM), but does not activate CCKBR-related signaling pathways. AP1153 aptamer sodium is internalized by pancreatic ductal adenocarcinoma (PDAC) cells in a receptor-mediated manner. AP1153 aptamer sodium can bioconjugate to the surface of fluorescent nanoparticles to facilitate nanoparticle delivery to PDAC tumors in vivo .

HY-D2165

AF 594 streptavidin	Fluorescent Dye	Others
AF 594 streptavidin is a bioconjugating agent. It consists of AF 594 and streptomycin, a streptomycin derivative of the red fluorescent dye AF 594. AF 594 has high fluorescence quantum yield and high photostability (maximum absorption wavelength 586 nm, maximum emission wavelength 613 nm). AF 594 streptavidin can be selectively conjugated to streptavidin-modified molecules via a streptomycin-modifying group for fluorescent labeling and spectroscopic analysis.

HY-161177

PROTAC KRAS G12D degrader 2	PROTACs Ras	Infection
PROTAC KRAS G12D degrades SARS-CoV-2, 3-curd trypsin-like protease (3CLPro). Protac KRAS G12D degrades SARS-CoV-2, 3-curd trypsin-like protease (3CLPRO). The PROTAC molecule is designed by partially coupling a GC-376-based dipeptidyl 3CLPro ligand with pomadomide via a piperazine-piperidine linker .

Cat. No.	Product Name

HY-L167

Boronic Acid Compound Library	7 compounds
Boric acid is a stable and usually non-toxic group widely used in modern synthesis to form C-C and C-heteroatom bonds. Boric acid exhibits exquisite reversible coordination characteristics and can be explored as a molecular construction tool, with specific mechanisms for controlling the structure and biological characteristics of bioconjugates. Boric acid has various activities, such as anticancer, antibacterial, and antiviral activities. In drugs, boric acid mainly exists in the form of arylboronic acid. In addition to this form, heterocycles containing boric acid, such as pyridine, pyrrole, and indole derivatives, are also very useful in pharmaceutical chemistry. Molecular modification by introducing boric acid groups into bioactive molecules has been shown to alter selectivity, physicochemical, and pharmacokinetic characteristics, and improve existing activity. MCE designs a unique collection of 7 boronic acid compounds. It is a good tool to be used for research on cancer and other diseases.

Boronic Acid Compound Library

7 compounds

Boric acid is a stable and usually non-toxic group widely used in modern synthesis to form C-C and C-heteroatom bonds. Boric acid exhibits exquisite reversible coordination characteristics and can be explored as a molecular construction tool, with specific mechanisms for controlling the structure and biological characteristics of bioconjugates. Boric acid has various activities, such as anticancer, antibacterial, and antiviral activities. In drugs, boric acid mainly exists in the form of arylboronic acid. In addition to this form, heterocycles containing boric acid, such as pyridine, pyrrole, and indole derivatives, are also very useful in pharmaceutical chemistry. Molecular modification by introducing boric acid groups into bioactive molecules has been shown to alter selectivity, physicochemical, and pharmacokinetic characteristics, and improve existing activity.

MCE designs a unique collection of 7 boronic acid compounds. It is a good tool to be used for research on cancer and other diseases.

Cat. No.	Product Name	Type

HY-134566

NBD-X, SE

Fluorescent Dyes/Probes

NBD-X, SE, the acceptor fluorophore, can be used to create environment sensitive bioconjugates .

NBD-X, SE	Fluorescent Dyes/Probes
NBD-X, SE, the acceptor fluorophore, can be used to create environment sensitive bioconjugates .

HY-15943

6-TAMRA 1 Publications Verification 6-Carboxytetramethylrhodamine	Fluorescent Dyes/Probes
6-TAMRA has been a widely used fluorophore for preparing bioconjugates, especially fluorescent antibody and avidin derivatives used in immunochemistry.

HY-W040291

7-Hydroxy-4-methylcoumarin-3-acetic acid, SE	Fluorescent Dyes/Probes
7-Hydroxy-4-methylcoumarin-3-acetic acid, SE is a blue fluorophore that has pH-dependent and environment-sensitive fluorescence. It is widely used for preparing bioconjugates of blue fluorescence.

HY-D2165

AF 594 streptavidin	Fluorescent Dyes/Probes
AF 594 streptavidin is a bioconjugating agent. It consists of AF 594 and streptomycin, a streptomycin derivative of the red fluorescent dye AF 594. AF 594 has high fluorescence quantum yield and high photostability (maximum absorption wavelength 586 nm, maximum emission wavelength 613 nm). AF 594 streptavidin can be selectively conjugated to streptavidin-modified molecules via a streptomycin-modifying group for fluorescent labeling and spectroscopic analysis.

AF 594 streptavidin

Fluorescent Dyes/Probes

AF 594 streptavidin is a bioconjugating agent. It consists of AF 594 and streptomycin, a streptomycin derivative of the red fluorescent dye AF 594. AF 594 has high fluorescence quantum yield and high photostability (maximum absorption wavelength 586 nm, maximum emission wavelength 613 nm). AF 594 streptavidin can be selectively conjugated to streptavidin-modified molecules via a streptomycin-modifying group for fluorescent labeling and spectroscopic analysis.

Cat. No.	Product Name		Classification

HY-135140

Methyltetrazine-Amine

Tetrazine

Methyltetrazine-Amine, a tetrazine compound, is used for the site-specific dual functionalization of the resulting bioconjugates .

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
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Screening Libraries

Fluorescent Dye

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