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Results for "

citric acid-induced coughing

" in MedChemExpress (MCE) Product Catalog:

3

Inhibitors & Agonists

2

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0352
    Tuberostemonine
    1 Publications Verification

    		 Parasite Infection
    Tuberostemonine is a stenine alkaloid that can be isolated from Stemona tuberosa and Stemona sessifolia. Tuberostemonine is an antimalarial agent that has inhibitory activity against Ferredoxin-NADP + reductases (FNRs) from Plasmodium falciparum (PfFNR). Tuberostemonine can reduce the number of citric acid-induced coughs in guinea pigs. Tuberostemonine decreases bronchoalveolar lavage fluid (BALF), neutrophil and macrophage infiltration and reduces peribronchial and perivascular inflammatory cell infiltration in mouse model of acute lung inflammation. Tuberostemonine has a level of activity as a feeding deterrent .
    Tuberostemonine
  • HY-19633A
    CS-003

    		Endogenous Metabolite Neurological Disease
    CS-003 is a triple neurokinin receptor antagonist with activity in inhibiting neurokinin-related respiratory diseases. CS-003 exhibits high affinity for human neurokinin 1, 2 and 3 receptors, withKi values of 2.3 nM, 0.54 nM and 0.74 nM respectively. The Ki values of CS-003 on the guinea pig neurokinin receptor are 5.2 nM, 0.47 nM and 0.71 nM respectively, showing superior inhibitory effect. CS-003 significantly inhibits the formation of inositol phosphate involving substance P, neurokinin A and neurokinin B through competitive antagonism. CS-003 significantly inhibits citric acid-induced cough, and its effect is better than other selective neurokinin receptor antagonists .
    CS-003
  • HY-N18266
    10-Hydroxycroomine

    		Others Inflammation/Immunology
    10-Hydroxycroomine is a croomine-type alkaloid. 10-Hydroxycroomine can be isolated from the roots of Stemona tuberosa. 10-Hydroxycroomine produces a non-statistically significant reduction in Citric acid (HY-N1428)-induced coughing. 10-Hydroxycroomine can be used for the research of cough .
    10-Hydroxycroomine

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