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deuterium substitute

" in MedChemExpress (MCE) Product Catalog:

28

Inhibitors & Agonists

28

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0614S
    Sucralose-d6

    E955-d6; Trichlorosucrose-d6

    		 Endogenous Metabolite Cancer
    Sucralose-d6 is deuterium labeled Sucralose. Sucralose?(E955; Trichlorosucrose) is a?non-nutritive?artificial?sweetener and sugar substitute. Sucralose can activate a conserved neural fasting response and thereby exerts an appetite-stimulating effect in rodents .
    Sucralose-d6
  • HY-N0216S
    Benzoic acid-d5
    1 Publications Verification

    		 Bacterial Fungal Endogenous Metabolite Infection
    Benzoic acid-d5 is a deuterium substitute for Benzoic acid. Benzoic acid is an aromatic alcohol that occurs naturally in many plants and is a common additive in food, beverages, cosmetics and other products. Benzoic acid can act as a preservative by inhibiting bacteria and fungi .
    Benzoic acid-d5
  • HY-W011927S
    4,4'-Sulfonyldiphenol-d8
    1 Publications Verification

    Bisphenol S (4,4'-Sulfonyldiphenol)-d8

    		 Isotope-Labeled Compounds Estrogen Receptor/ERR Histone Methyltransferase Thyroid Hormone Receptor PI3K Akt mTOR Androgen Receptor Cardiovascular Disease Metabolic Disease Inflammation/Immunology Endocrinology Cancer
    4,4'-Sulfonyldiphenol-d8 (Bisphenol S (4,4'-Sulfonyldiphenol)-d8) is the deuterium labeled 4,4'-Sulfonyldiphenol (HY-W011927).4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone), a substitute for Bisphenol A (HY-18260), is widely used in industrial and consumer products. 4,4'-Sulfonyldiphenol is an estrogen receptor (ER) agonist and can competitively bind to thyroid hormone receptors (TR) with IC50 values for TRα and TRβ are 2650 μM and 2294 μM respectively, thereby affecting breast development and reducing the expression of androgen receptor (AR) in fetal testes. 4,4'-Sulfonyldiphenol promotes the progression of glioblastoma by upregulating the EZH2 mediated PI3K/AKT/mTOR pathway. Under chronic exposure, 4,4'-Sulfonyldiphenol can cause significant lipid deposition and dyslipidemia in the mouse liver by upregulating JunB and Atf3, and has a role in causing obesity at low doses. 4,4'-Sulfonyldiphenol induces intestinal inflammation by altering the intestinal microbiome. 4,4'-Sulfonyldiphenol accelerates the progression of atherosclerosis in zebrafish embryo larvae.
    4,4'-Sulfonyldiphenol-d8
  • HY-W011834S
    2'-O-Methylcytidine-d3

    		Isotope-Labeled Compounds HCV Infection
    2'-O-Methylcytidine-d3 is deuterium labeled 2'-O-Methylcytidine (HY-W011834). 2'-O-Methylcytidine is a 2'-substituted nucleoside as a inhibitor of HCV replication. 2'-O-Methylcytidine inhibits RNA-dependent RNA polymerase (NS5B)-catalyzed RNA synthesis in vitro, in a manner that is competitive with substrate nucleoside triphosphate.
    2'-O-Methylcytidine-d3
  • HY-B0400S
    D-Sorbitol-d8

    Sorbitol-d8; D-Glucitol-d8

    		 Endogenous Metabolite Others
    D-Sorbitol-d8 is the deuterium labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and dietary supplement .
    D-Sorbitol-d8
  • HY-113123S1
    LysoPC(14:0/0:0)-d7

    14:0 Lyso PC-d7; 1-myristoyl-sn-glycero-3-phosphatidylcholine-d7

    		 Isotope-Labeled Compounds Endogenous Metabolite Neurological Disease Metabolic Disease
    LysoPC(14:0/0:0)-d7 (14:0 Lyso PC-d7) is deuterium labeled LysoPC(14:0/0:0). LysoPC(14:0/0:0) is a lysophospholipid (LyP). It is a monoglycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. LysoPC(14:0/0:0) has potent antispasmodic effect .
    LysoPC(14:0/0:0)-d7
  • HY-41494S
    O-Toluic acid-d7

    2-Methylbenzoic acid-d7

    		 Isotope-Labeled Compounds Endogenous Metabolite Others
    O-Toluic acid-d7 is the deuterium labeled o-Toluic acid . o-Toluic acid (2-Methylbenzoic acid) is a benzoic acid substituted by a methyl group at position 2. O-Toluic acid plays a role as a xenobiotic metabolite.
    O-Toluic acid-d7
  • HY-76547S2
    p-Toluic acid-d3

    4-Methylbenzoic acid-d3

    		 Endogenous Metabolite Others
    p-Toluic acid-d3 is the deuterium labeled p-Toluic acid . p-Toluic acid (4-Methylbenzoic acid) is a substituted benzoic acid and can be used as an intermediate for the synthesis of para-aminomethylbenzoic acid (PAMBA), p-tolunitrile, etc.
    p-Toluic acid-d3
  • HY-76547S1
    p-Toluic acid-d7

    4-Methylbenzoic acid-d7

    		 Endogenous Metabolite Others
    p-Toluic acid-d7 is the deuterium labeled p-Toluic acid . p-Toluic acid (4-Methylbenzoic acid) is a substituted benzoic acid and can be used as an intermediate for the synthesis of para-aminomethylbenzoic acid (PAMBA), p-tolunitrile, etc.
    p-Toluic acid-d7
  • HY-17507S
    Pantoprazole-d6

    BY1023-d6; SKF96022-d6

    		 Isotope-Labeled Compounds Proton Pump Autophagy Apoptosis Inflammation/Immunology Cancer
    Pantoprazole-d6 is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
    Pantoprazole-d6
  • HY-B0256S
    Azathioprine-d3

    BW 57-322-d3

    		 Isotope-Labeled Compounds Others
    Azathioprine-d3 (BW 57-322-d3) is the deuterium labeled Azathioprine (HY-B0256). Azathioprine (BW 57-322) is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis .
    Azathioprine-d3
  • HY-U00131S
    Sulfabrom-d4

    N 3517-d4; Sulfabromomethazine-d4

    		 Isotope-Labeled Compounds Others
    Sulfabrom-d4 (N 3517-d4) is is the deuterium labeled Sulfabrom (HY-U00131). Sulfabrom is a long-acting Sulfonamide that is used for the treatment of coccidiosis and various bacterial infections in the poultry, swine and cattle .
    Sulfabrom-d4
  • HY-B2023S
    Chlorotoluron-d6

    		Isotope-Labeled Compounds Environmental Pollutants Others
    Chlorotoluron-d6 is the deuterium labeled Chlorotoluron . Chlorotoluron (Chlortoluron) is a substituted phenylurea herbicide, is widely used for selective weed control in cereals crops and is an environmental pollutant .
    Chlorotoluron-d6
  • HY-15592S2
    Cabotegravir-d3-1

    GSK-1265744-d3-1; S/GSK1265744-d3-1

    		 Isotope-Labeled Compounds HIV Integrase Infection
    Cabotegravir d3-1 (GSK-1265744-d3-1) is a deuterium substitute of Cabotegravir. Cabotegravir is a potent HIV integrase inhibitor used in AIDS research
    Cabotegravir-d3-1
  • HY-76547S
    p-Toluic acid-d4

    4-Methylbenzoic acid-d4

    		 Endogenous Metabolite Others
    p-Toluic acid-d4 is the deuterium labeled p-Toluic acid . p-Toluic acid (4-Methylbenzoic acid) is a substituted benzoic acid and can be used as an intermediate for the synthesis of para-aminomethylbenzoic acid (PAMBA), p-tolunitrile, etc.
    p-Toluic acid-d4
  • HY-13600S1
    Clobetasol propionate-d5

    		Isotope-Labeled Compounds Cytochrome P450 Inflammation/Immunology
    Clobetasol propionate-d5 is a deuterium substitute of Clobetasol propionate. Clobetasol propionate is a potent, selective CYP3A5 inhibitor with a IC50 of 0.206 μM and has potential for use in the study of psoriasis and other skin diseases .
    Clobetasol propionate-d5
  • HY-B0400S7
    D-Sorbitol-d1-2

    Sorbitol-d1-2; D-Glucitol-d1-2

    		 Endogenous Metabolite Others
    D-Sorbitol-d-2 is the deuterium labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and di
    D-Sorbitol-d1-2
  • HY-B0400S10
    D-Sorbitol-d4

    Sorbitol-d4; D-Glucitol-d4

    		 Endogenous Metabolite Others
    D-Sorbitol-d4 is the deuterium labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and diet
    D-Sorbitol-d4
  • HY-B0400S4
    D-Sorbitol-d2

    Sorbitol-d2; D-Glucitol-d2

    		 Isotope-Labeled Compounds Endogenous Metabolite Others
    D-Sorbitol-d2 is the deuterium labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and diet
    D-Sorbitol-d2
  • HY-B0400S9
    D-Sorbitol-d2-2

    Sorbitol-d2-2; D-Glucitol-d2-2

    		 Endogenous Metabolite Others
    D-Sorbitol-d2-2 is the deuterium labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and di
    D-Sorbitol-d2-2
  • HY-B0400S8
    D-Sorbitol-d2-1

    Sorbitol-d2-1; D-Glucitol-d2-1

    		 Endogenous Metabolite Others
    D-Sorbitol-d2-1 is the deuterium labeled D-Sorbitol. D-Sorbitol (Sorbitol) is a six-carbon sugar alcohol and can used as a sugar substitute. D-Sorbitol can be used as a stabilizing excipient and/or isotonicity agent, sweetener, humectant, thickener and di
    D-Sorbitol-d2-1
  • HY-W014895S
    Ethyl 4-methylbenzenesulfonate-d5

    Ethyl p-toluenesulfonate-d5; Ethyl tosylate-d5

    		 Isotope-Labeled Compounds Drug Intermediate Others
    Ethyl 4-methylbenzenesulfonate-d5 (Ethyl p-toluenesulfonate-d5; Ethyl tosylate-d5) is deuterium labeled Ethyl 4-methylbenzenesulfonate (HY-W014895). Ethyl 4-methylbenzenesulfonate is a drug intermediate that can be used for the synthesis of alkyl and substituted alkyl fluorides.
    Ethyl 4-methylbenzenesulfonate-d5
  • HY-17507S1
    Pantoprazole-d3

    BY1023-d3; SKF96022-d3

    		 Isotope-Labeled Compounds Proton Pump Autophagy Apoptosis Inflammation/Immunology Cancer
    Pantoprazole-d3 is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
    Pantoprazole-d3
  • HY-W739793
    Pantoprazole-d8 sodium

    BY1023-d8 sodium; SKF96022-d8 sodium

    		 Isotope-Labeled Compounds Proton Pump Autophagy Apoptosis Bacterial Inflammation/Immunology Cancer
    Pantoprazole-d8 (BY1023-d8) sodium is a deuterium labeled Pantoprazole (HY-17507). Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H +/K +-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
    Pantoprazole-d8 sodium
  • HY-17507S2
    Pantoprazole-d8

    BY1023-d8; SKF96022-d8

    		 Isotope-Labeled Compounds Bacterial Autophagy Apoptosis Proton Pump Inflammation/Immunology Cancer
    Pantoprazole-d8 (BY1023-d8) is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H +/K +-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
    Pantoprazole-d8
  • HY-17507S4
    Pantoprazole-d4

    BY1023-d4; SKF96022-d4

    		 Isotope-Labeled Compounds Inflammation/Immunology Cancer
    Pantoprazole-d4 (BY1023-d4) is deuterium labeled Pantoprazole. Pantoprazole (BY10232) is an orally active and potent proton pump inhibitor (PPI) . Pantoprazole, a substituted benzimidazole, is a potent H +/K +-ATPase inhibitor with an IC50 of 6.8 μM. Pantoprazole improves pH stability and has anti-secretory, anti-ulcer activities. Pantoprazole significantly increased tumor growth delay combined with Doxorubicin (HY-15142) .
    Pantoprazole-d4
  • HY-W725504
    2-Hydroxy-3-methylbutanoic acid-d7

    		Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease
    2-Hydroxy-3-methylbutanoic acid-d7 is the deuterium labeled 2-Hydroxy-3-methylbutanoic acid (HY-W008150). 2-Hydroxy-3-methylbutanoic acid is an α-hydroxy analogue of valine and a valine precursor that reduces urea excretion. 2-Hydroxy-3-methylbutanoic acid can promote the growth of chickens and rats, and is converted into valine in the body, participating in protein synthesis and maintaining nitrogen balance, thereby supporting animal growth and development. 2-Hydroxy-3-methylbutanoic acid has a more significant effect on the valine-deficient dietary model. 2-Hydroxy-3-methylbutanoic acid is mainly used in animal nutrition research to evaluate its potential application as a nitrogen source substitute in feed .
    2-Hydroxy-3-methylbutanoic acid-d7
  • HY-134058S
    3-Heptanol-d4

    Butylethylcarbinol-d4

    		 Isotope-Labeled Compounds Biochemical Assay Reagents Others
    3-Heptanol-d4 (Butylethylcarbinol-d4) is the deuterium labeled 3-Heptanol (HY-134058). 3-Heptanol is a biotransformation product of n-heptane. 3-Heptanol can act as the building block in the synthesis of 4-(3-adamantan-1-yl-ureido)-butyric acid and cyclohexanecarboxylic acid derivatives as sEH inhibitors. 3-Heptanol can be used as a solvent to form microenvironments around single-walled carbon nanotubes. 3-Heptanol can be used in the preperation of substituted pyrimidine derivatives as C1 domain-targeted isophthalate analogs to study their binding affinities towards PKCα isoform .
    3-Heptanol-d4

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