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Results for "

hybrid+compound

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-149958
    Antileishmanial agent-17

    		Parasite Infection
    Antileishmanial agent-17 is a coumarin hybrid compound with antileishmanial effects (IC50 <0.78 μM). Antileishmanial agent-17 is safe to normal VERO cells. Antileishmanial agent-17 binds to folate pathway enzymes pteridine reductase and DHFR-TS. And Antileishmanial agent-17 shows the most potent with IC50 value of 0.40 μM against promastigote and 0.68 μM against amastigote, respectivley.
    Antileishmanial agent-17
  • HY-173213
    Antileishmanial agent-33

    		Parasite Infection Inflammation/Immunology
    Antileishmanial agent-33 (4e), a hybrid compound of grandisin and machilin G, shows moderate activity on promastigotes (IC50 of 38.1 μM). Antileishmanial agent-33 (4e) shows potential as an antileishmanial agent for the research of cutaneous leishmaniasis (CL) .
    Antileishmanial agent-33
  • HY-128346
    PQM130

    		Amyloid-β Neurological Disease
    PQM130, a Feruloyl-Donepezil Hybrid compound with brain penatration, is a multitarget agent candidate against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity. PQM130 acts as a neuroprotective compound for anti-AD agent development .
    PQM130
  • HY-145294
    ROCK2-IN-5

    		ROCK Neurological Disease
    ROCK2-IN-5 (compound 1d) is a hybrid compound containing structural fragments of the Rho kinase inhibitor fasudil and the NRF2 inducers caffeic and ferulic acids. ROCK2-IN-5 has good multitarget profile and good tolerability. ROCK2-IN-5 has the potential for thr research of Amyotrophic lateral sclerosis (ALS) with a SOD1 mutation .
    ROCK2-IN-5

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