Antileishmanial agent-17
Antileishmanial agent-17 is a coumarin hybrid compound with antileishmanial effects (IC50 <0.78 μM). Antileishmanial agent-17 is safe to normal VERO cells. Antileishmanial agent-17 binds to folate pathway enzymes pteridine reductase and DHFR-TS. And Antileishmanial agent-17 shows the most potent with IC50 value of 0.40 μM against promastigote and 0.68 μM against amastigote, respectivley.
For research use only. We do not sell to patients.
- CAS No.: 2934738-40-4
- Formula: C27H37N5O5
- Molecular Weight:511.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero | CC50 |
244.3 μM
Compound: 14b
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Cytotoxicity against green monkey Vero cells incubated for 72 hrs by crystal violet staining analysis
Cytotoxicity against green monkey Vero cells incubated for 72 hrs by crystal violet staining analysis
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[PMID: 37031526] |
Antileishmanial agent-17 (compound 14b) inhibits folate pathway with inhibitory rates of 82% and 91% against Folic acid, and 88% and 91% agaisnt Folinic acid, with 20 μM and 100 μM, respectivley[1].
Antileishmanial agent-17 shows insignificant cytotoxicity against African green monkey kidney cells (VERO cells), with CC50 of 244.3 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2934738-40-4
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Molecular Weight 511.61
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Formula C27H37N5O5
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SMILES
O=C(NCCCCCCN1C=C(N=N1)CN2CCOCC2)C(C(O3)=O)=CC(C=C4)=C3C=C4OCCCC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antileishmanial agent-17 Related Classifications
HY-149958 Related Classifications
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