2. Anti-infection
  3. Parasite
  4. Antileishmanial agent-17

Antileishmanial agent-17 is a coumarin hybrid compound with antileishmanial effects (IC50 <0.78 μM). Antileishmanial agent-17 is safe to normal VERO cells. Antileishmanial agent-17 binds to folate pathway enzymes pteridine reductase and DHFR-TS. And Antileishmanial agent-17 shows the most potent with IC50 value of 0.40 μM against promastigote and 0.68 μM against amastigote, respectivley.

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Antileishmanial agent-17

Antileishmanial agent-17 Chemical Structure

CAS No. : 2934738-40-4

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Antileishmanial agent-17 Related Antibodies

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Description

Antileishmanial agent-17 is a coumarin hybrid compound with antileishmanial effects (IC50 <0.78 μM). Antileishmanial agent-17 is safe to normal VERO cells. Antileishmanial agent-17 binds to folate pathway enzymes pteridine reductase and DHFR-TS. And Antileishmanial agent-17 shows the most potent with IC50 value of 0.40 μM against promastigote and 0.68 μM against amastigote, respectivley.

Cellular Effect
Cell Line Type Value Description References
Vero CC50
244.3 μM
Compound: 14b
Cytotoxicity against green monkey Vero cells incubated for 72 hrs by crystal violet staining analysis
Cytotoxicity against green monkey Vero cells incubated for 72 hrs by crystal violet staining analysis
[PMID: 37031526]
In Vitro

Antileishmanial agent-17 (compound 14b) inhibits folate pathway with inhibitory rates of 82% and 91% against Folic acid, and 88% and 91% agaisnt Folinic acid, with 20 μM and 100 μM, respectivley[1]. Antileishmanial agent-17 shows insignificant cytotoxicity against African green monkey kidney cells (VERO cells), with CC50 of 244.3 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antileishmanial agent-17 Related Antibodies
Molecular Weight

511.61

Formula

C27H37N5O5
CAS No.
SMILES

O=C(NCCCCCCN1C=C(N=N1)CN2CCOCC2)C(C(O3)=O)=CC(C=C4)=C3C=C4OCCCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Antileishmanial agent-17 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antileishmanial agent-172934738-40-4Antileishmanial agent17Antileishmanial agent 17ParasiteantileishmanialAfrican green monkey kidney cellsInhibitorinhibitorinhibit

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