2. Anti-infection
  3. Parasite
  4. Antileishmanial agent-17

Antileishmanial agent-17 is a coumarin hybrid compound with antileishmanial effects (IC50 <0.78 μM). Antileishmanial agent-17 is safe to normal VERO cells. Antileishmanial agent-17 binds to folate pathway enzymes pteridine reductase and DHFR-TS. And Antileishmanial agent-17 shows the most potent with IC50 value of 0.40 μM against promastigote and 0.68 μM against amastigote, respectivley.

For research use only. We do not sell to patients.

Antileishmanial agent-17 Chemical Structure

Antileishmanial agent-17 Chemical Structure

CAS No. : 2934738-40-4

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Antileishmanial agent-17 Related Antibodies

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Description

Antileishmanial agent-17 is a coumarin hybrid compound with antileishmanial effects (IC50 <0.78 μM). Antileishmanial agent-17 is safe to normal VERO cells. Antileishmanial agent-17 binds to folate pathway enzymes pteridine reductase and DHFR-TS. And Antileishmanial agent-17 shows the most potent with IC50 value of 0.40 μM against promastigote and 0.68 μM against amastigote, respectivley.

In Vitro

Antileishmanial agent-17 (compound 14b) inhibits folate pathway with inhibitory rates of 82% and 91% against Folic acid, and 88% and 91% agaisnt Folinic acid, with 20 μM and 100 μM, respectivley[1]. Antileishmanial agent-17 shows insignificant cytotoxicity against African green monkey kidney cells (VERO cells), with CC50 of 244.3 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antileishmanial agent-17 Related Antibodies
Molecular Weight

511.61

Formula

C27H37N5O5
CAS No.
SMILES

O=C(NCCCCCCN1C=C(N=N1)CN2CCOCC2)C(C(O3)=O)=CC(C=C4)=C3C=C4OCCCC
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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Antileishmanial agent-17 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antileishmanial agent-172934738-40-4Antileishmanial agent17Antileishmanial agent 17ParasiteantileishmanialAfrican green monkey kidney cellsInhibitorinhibitorinhibit

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