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Results for "

intracellular protein leakage

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N1616
    1β-Hydroxyeuscaphic acid

    		Apoptosis Others
    1β-Hydroxyeuscaphic acid has significant hepatoprotective activity by lowering the leakage of intracellular enzymes, reducing the oxidation of proteins and decreasing the incidence of apoptosis .
    1β-Hydroxyeuscaphic acid
  • HY-169160
    Anti-MRSA agent 18

    		Bacterial Infection
    Anti-MRSA agent 18 (E17) is an inhibitor of MRSA with MIC values of 2 μg/mL for S. aureus and 4 μg/mL for MRSA, respectively. Anti-MRSA agent 18 interacts with bacterial cell membrane phosphatidylglycerol and cardiolipin, causing changes in cell membrane permeability and polarization, increased intracellular ROS, and DNA and protein leakage, thereby accelerating bacterial death .
    Anti-MRSA agent 18
  • HY-173239
    Antibacterial agent 274

    		Bacterial Infection
    Antibacterial agent 274 (Compound 18b) is a membrane-targeting antibacterial agent that demonstrates a MIC of 8 μg/mL against Acinetobacter baumannii ATCC 17978. By disrupting bacterial membrane integrity, it induces intracellular ROS accumulation and causes leakage of DNA and proteins, thereby exhibiting potent antibacterial activity. This compound is suitable for research applications targeting Gram-negative bacterial infections .
    Antibacterial agent 274
  • HY-173238
    Antibacterial agent 273

    		Bacterial Reactive Oxygen Species (ROS) Infection
    Antibacterial Agent 273 (Compound 15e) is a membrane-targeting antimicrobial agent that disrupts bacterial cell membranes, exhibiting a MIC of 4 μg/mL against Staphylococcus aureus. By compromising membrane integrity, it induces leakage of intracellular nucleic acids and proteins, suppresses bacterial metabolic activity, and triggers the accumulation of reactive oxygen species (ROS). Antibacterial Agent 273 is suitable for research on infections caused by Staphylococcus aureus .
    Antibacterial agent 273
  • HY-161364
    Antibacterial agent 200

    		Bacterial Inflammation/Immunology
    Antibacterial agent 200 (pyridyl HH 7), a unique hydrazyl hydroxycoumarin (HH), has strong antibacterial efficacy and broad antibacterial spectrum with MIC values ranging from 0.5 to 32 μg/mL for Gram-positive and Gram-negative bacteria. Antibacterial agent 200 exhibits a good inhibition against Pseudomonas aeruginosa 27853 with a low MIC value of 0.5 μg/mL. Antibacterial agent 200 can eradicate the integrity of bacterial membrane, result in the leakage of intracellular proteins, and interact with bacterial DNA gyrase via non-covalent binding .
    Antibacterial agent 200
  • HY-168258
    Antibiofilm agent-13

    		Bacterial Infection
    Antibiofilm agent-13 (compound 14b) is a potent antibacterial agent that displays a broad-spectrum antimicrobial activity. Antibiofilm agent-13 could disintegrate the integrity of bacterial cell membranes by destroying transmembrane potential and enhancing membrane permeability, and causing the generation of intracellular ROS and the leakage of DNA and proteins, ultimately leading to bacterial death. Antibiofilm agent-13 inhibits both Gram-positive bacteria (MIC of 0.5-1 μg/mL) and Gram-negative bacteria (MIC of 1-32 μg/mL) .
    Antibiofilm agent-13
  • HY-184296
    CPO 4

    		Bacterial DNA/RNA Synthesis Infection
    CPO 4 is a DNA-targeting antibacterial agent. CPO 4 intercalates into DNA to form a CPO 4-DNA complex, thereby blocking DNA replication. CPO 4 disrupts the metabolic activity of bacteria. CPO 4 induces intracellular protein leakage in bacteria. CPO 4 can be used for the research of drug-resistant bacterial infections .
    CPO 4
  • HY-183751
    Antibacterial agent 346

    		Bacterial Reactive Oxygen Species (ROS) Infection
    Antibacterial agent 346 is a broad-spectrum Antibacterial agent and BsFtsZ inhibitor, with an IC50 of 69.67 μg/mL against BsFtsZ. Antibacterial agent 346 selectively binds to phosphatidylglycerol, disrupts membrane integrity, increases permeability, triggers depolarization and causes intracellular protein leakage. Antibacterial agent 346 induces intracellular ROS accumulation, which in turn triggers oxidative stress and cell death. Antibacterial agent 346 eradicates mature biofilms formed by Gram-positive and Gram-negative bacteria. Antibacterial agent 346 exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus and Acinetobacter baumannii. Antibacterial agent 346 can be used in the research of bacterial infections .
    Antibacterial agent 346

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