2. Anti-infection Cell Cycle/DNA Damage
  3. Bacterial DNA/RNA Synthesis
  4. CPO 4

CPO 4 is a DNA-targeting antibacterial agent. CPO 4 intercalates into DNA to form a CPO 4-DNA complex, thereby blocking DNA replication. CPO 4 disrupts the metabolic activity of bacteria. CPO 4 induces intracellular protein leakage in bacteria. CPO 4 can be used for the research of drug-resistant bacterial infections.

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CPO 4

CPO 4 Chemical Structure

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CPO 4 Related Antibodies

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Description

CPO 4 is a DNA-targeting antibacterial agent. CPO 4 intercalates into DNA to form a CPO 4-DNA complex, thereby blocking DNA replication. CPO 4 disrupts the metabolic activity of bacteria. CPO 4 induces intracellular protein leakage in bacteria. CPO 4 can be used for the research of drug-resistant bacterial infections[1].

In Vitro

CPO 4 (0.001-0.416 mM) potently inhibits the growth of Enterococcus faecalis p1-2007226001 with an MIC of 0.001 mM, and exhibits varying levels of antibacterial activity against 10 additional tested bacterial strains[1].
CPO 4 (0.006-0.208 mM; 4 h) exhibits negligible hemolytic activity against red blood cells, with a hemolysis rate below 5% at 0.208 mM after 4 h, and preserves RBC structural integrity at 0.052 mM[1].
CPO 4 (14 bacterial passages) displays a low propensity for inducing resistance in Enterococcus faecalis p1-2007226001, with stable MIC values over 14 passages[1].
CPO 4 (0.5×-4×MIC) dose-dependently reduces the metabolic activity of Enterococcus faecalis p1-2007226001, with the greatest reduction at 4×MIC[1].
CPO 4 (0.5×-4×MIC) dose-dependently induces protein leakage from Enterococcus faecalis p1-2007226001, reaching a maximum leaked protein concentration of 25 μg/mL at 4×MIC[1].
CPO 4 exhibits favorable drug-likeness and pharmacokinetic properties, with 0 Lipinski violations, a bioavailability score of 0.55, high predicted GI absorption, and no predicted blood-brain barrier permeation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CPO 4 Related Antibodies
In Vivo

CPO 4 (6-13 μM; single dose at 0.5 h post-infection) exerts in vivo antibacterial activity against Enterococcus faecalis p1-2007226001 in Galleria mellonella, increasing the 5-day survival rate of infected larvae from 20% to 50% at a dose of 0.013 mM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: larvae[1]
Dosage: 6 and 13 μM
Administration: single dose at 0.5 h post-infection
Result: Increased the 5-day survival rate of infected larvae from 20% to 50%.
Achieved a 5-day survival rate higher than the saline control but lower than the 0.013 mM group.
Molecular Weight

313.70

Formula

C15H8ClN3O3
SMILES

CC1=NC(C2=C(C3=C(OC2=O)C=CC=C3)Cl)=C(C(O)=N1)C#N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CPO 4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CPO 4CPO4CPO-4BacterialDNA/RNA SynthesisDNA replicationGalleria mellonellaDNAred blood cellsacridine orangeEnterococcus faecalis p1-2007226001drug-resistant bacterial infectionsintracellular protein leakagebacterial metabolic activitycalf thymus DNAInhibitorinhibitorinhibit

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