Antibacterial agent 346

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Antibacterial agent 346 (Compound H14d) is a broad-spectrum Antibacterial agent and BsFtsZ inhibitor, with an IC₅₀ of 69.67 μg/mL against BsFtsZ. Antibacterial agent 346 selectively binds to phosphatidylglycerol, disrupts membrane integrity, increases permeability, triggers depolarization and causes intracellular protein leakage. Antibacterial agent 346 induces intracellular ROS accumulation, which in turn triggers oxidative stress and cell death. Antibacterial agent 346 eradicates mature biofilms formed by Gram-positive and Gram-negative bacteria. Antibacterial agent 346 exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus and Acinetobacter baumannii. Antibacterial agent 346 can be used in the research of bacterial infections.

For research use only. We do not sell to patients.

Antibacterial agent 346 Chemical Structure

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Antibacterial agent 346 (Multiple concentrations) inhibits the GTPase activity of BsFtsZ in a concentration-dependent manner, with an IC₅₀ of 69.67 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2	T_max	C_max	AUC_0-t	AUC_0-∞	CL	V_z	MRT_0-t	MRT_0-∞
Mice^[1]	2.5 mg/kg	i.v.	10.91 h	0.33 h	529 ng/mL	2687 ng·h/mL	8402 ng·h/mL	298 mL/h/kg	4684 mL/kg	2.79 h	15.68 h
Mice^[1]	5 mg/kg	i.v.	10.81 h	0.25 h	654 ng/mL	3318 ng·h/mL	10278 ng·h/mL	487 mL/min/kg	7588 mL/kg	2.79 h	15.53 h
Mice^[1]	10 mg/kg	i.v.	10.60 h	0.25 h	897 ng/mL	4555 ng·h/mL	13934 ng·h/mL	718 mL/h/kg	10976 mL/kg	2.78 h	15.24 h

In Vivo

Antibacterial agent 346 (10 mg/kg; single administration) exhibits in vivo antibacterial efficacy comparable to the first-line clinical antibiotic linezolid, with an 80% or higher survival rate of MRSA-infected Galleria mellonella larvae at 48 hours post-treatment^[1].
Antibacterial agent 346 (5-10 mg/kg) demonstrates potent in vivo anti-MRSA efficacy in a murine skin infection model, with 10 mg/kg achieving nearly complete wound healing and superior bacterial burden reduction compared to linezolid 10 mg/kg^[1].
Antibacterial agent 346 (5-10 mg/kg) displays robust in vivo antibacterial activity in a murine deep soft tissue MRSA infection model, with 10 mg/kg reducing bacterial burden by 3.5 log₁₀ CFU, surpassing the efficacy of linezolid 10 mg/kg^[1].
Antibacterial agent 346 (5-10 mg/kg) exhibits potent in vivo antibacterial activity in a systemic MRSA bacteremia model, with 10 mg/kg reducing blood and organ bacterial burdens more effectively than linezolid 10 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	larvae^[1]
Dosage:	10 mg/kg
Administration:	single administration
Result:	Maintained an 80% or higher survival rate within 48 hours post-infection.

Molecular Weight

602.55

Formula

C₃₃H₃₅IN₂O

SMILES

C[N+]1=C(/C=C/C2=CN(CCCCCCC)C3=C2C=CC=C3)OC(C4=CC=CC=C4)=C1C5=CC=CC=C5.[I-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ding H, et al. Rational molecular hybridization of indole-vinyl-substituted 4,5-diphenyloxazolium derivatives enables dual membrane and intracellular targeting for broad-spectrum antibacterial activity. Eur J Med Chem. 2026;314:118914.