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mPGES-2

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By Targets:	Amino acid Transporter (1) Ferroptosis (1) Glutathione Peroxidase (1) MDM-2/p53 (1) PGE synthase (1) Prostaglandin Receptor (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Endocrinology (1) Metabolic Disease (1)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Inhibitors & Agonists

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-179041

SZ0232	PGE synthase Prostaglandin Receptor MDM-2/p53 Amino acid Transporter Glutathione Peroxidase Ferroptosis	Metabolic Disease Endocrinology
SZ0232 is a selective *mPGES-2* inhibitor. SZ0232 binds to the active site of *mPGES-2* via hydrogen bonds and π-π stacking, reduces the production of prostaglandin E₂ (PGE₂) and blocks the PGE₂-EP3 pathway. SZ0232 regulates Ferroptosis by activating the heme-dependent p53/SLC7A11/GPX4 axis, inhibits lipid peroxidation, and protects renal tubules. SZ0232 enhances glucose-stimulated insulin secretion, inhibits β-cell senescence, and improves glucose homeostasis. SZ0232 reduces renal lipid accumulation, alleviates fibrosis, and ameliorates renal dysfunction in diabetic mice. SZ0232 inhibits renal cyst growth in polycystic kidney disease models. SZ0232 exhibits an insulinotropic effect that strengthens with the increase of animal age. SZ0232 can be used in studies related to type 2 diabetes, acute kidney injury, diabetic kidney disease, and autosomal dominant polycystic kidney disease ^[2] .

HY-RS19804

Ptges2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ptges2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ptges2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ptges2 Mouse Pre-designed siRNA Set A Ptges2 Mouse Pre-designed siRNA Set A

HY-RS11380

PTGES2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PTGES2 Human Pre-designed siRNA Set A contains three designed siRNAs for PTGES2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PTGES2 Human Pre-designed siRNA Set A PTGES2 Human Pre-designed siRNA Set A

Host:	Mouse (2)
Reactivity:	Human (2)
Application:	IHC-P (2) ICC/IF (2)
Isotype:	IgG2a (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1)
Modification:	Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P88595

	PTGES2 Antibody (YA8279) C9orf15; GBF-1; GBF1; mPGES-2; PGES2	IHC-P, ICC/IF	Human
	PTGES2 Antibody (YA8279) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to PTGES2.

HY-P88595A

	PTGES2 Antibody (YA8279)(PBS only) C9orf15; GBF-1; GBF1; mPGES-2; PGES2	IHC-P, ICC/IF	Human
	PTGES2 Antibody (YA8279) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to PTGES2.

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Ptges2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ptges2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ptges2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

PTGES2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PTGES2 Human Pre-designed siRNA Set A contains three designed siRNAs for PTGES2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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