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PTGES2 Antibody (YA8279)(PBS only)

(Synonyms: C9orf15; GBF-1; GBF1; mPGES-2; PGES2)

PTGES2 Antibody (YA8279) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to PTGES2.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG2a

  • Application:

    IHC-P, ICC/IF

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • PTGES2 Antibody (YA8279)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
Dilution Ratio 1:150-500 1:100-250

Product Details

Description

PTGES2 Antibody (YA8279) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to PTGES2.

  • Host Mouse
  • Species Reactivity
    Human
  • Calculated Molecular Weight Predicted band size: 41.8 kDa
Immunogen

Full length human recombinant protein of human PTGES2 produced in HEK293T cell.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG2a

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    PTGES2 is an Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro). The biological function and the GSH-dependent property of PTGES2 is still under debate. In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA)[1][2][3].

  • Subcellular Localization

    Golgi apparatus membrane,Cytoplasm, perinuclear region

  • Expression


    Tissue_Specificity: Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum; occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and trachea, but not in the thymus or lung. Overexpressed in colorectal cancer

  • Isoforms & Post-Translational Modification

    Q9H7Z7: 377 amino acids, molecular weight 41943 Da.

  • Subunit

    Homodimer

  • SwissProt ID

    Q9H7Z7

  • Synonyms

    C9orf15; GBF-1; GBF1; mPGES-2; PGES2

PTGES2 Antibody (YA8279)(PBS only) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • PTGES2 Antibody (YA8279)(PBS only) Product Image