PTGES2 Antibody (YA8279)
(Synonyms: C9orf15; GBF-1; GBF1; mPGES-2; PGES2)PTGES2 Antibody (YA8279) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to PTGES2.
-
Host:
Mouse
-
Isotype:
IgG
-
Application:
IHC-P, ICC/IF
-
Reactivity :
Human
-
Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:150-500 | 1:100-250 |
Product Details
PTGES2 Antibody (YA8279) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to PTGES2.
-
Host Mouse
-
Clonality Monoclonal
-
Species ReactivityHuman
-
Calculated Molecular Weight Predicted band size: 41.8 kDa
Full length human recombinant protein of human PTGES2 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Solution
-
Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
PTGES2 is an Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro). The biological function and the GSH-dependent property of PTGES2 is still under debate. In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA)[1][2][3].
-
Subcellular Localization
Golgi apparatus membrane,Cytoplasm, perinuclear region
-
Expression
Tissue_Specificity: Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum; occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and trachea, but not in the thymus or lung. Overexpressed in colorectal cancer -
Isoforms & Post-Translational Modification
Q9H7Z7: 377 amino acids, molecular weight 41943 Da.
-
Subunit
Homodimer
-
SwissProt ID
-
Synonyms
C9orf15; GBF-1; GBF1; mPGES-2; PGES2
Documentation
References
[1]. Watanabe K, et al. Essential 110Cys in active site of membrane-associated prostaglandin E synthase-2. Biochem Biophys Res Commun. 2003 Jun 27;306(2):577-81. [Content Brief]
[2]. Yamada T, et al. PGH2 degradation pathway catalyzed by GSH-heme complex bound microsomal prostaglandin E2 synthase type 2: the first example of a dual-function enzyme. Biochemistry. 2007 Jul 17;46(28):8414-24. [Content Brief]
[3]. Watanabe K, et al. Studies on membrane-associated prostaglandin E synthase-2 with reference to production of 12L-hydroxy-5,8,10-heptadecatrienoic acid (HHT). Biochem Biophys Res Commun. 2008 Mar 21;367(4):782-6. [Content Brief]
Powered by Bioz
