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ulcer formation

" in MedChemExpress (MCE) Product Catalog:

By Targets:	15-PGDH (1) Bacterial (1) Drug Derivative (1) Histamine Receptor (1) Na+/K+ ATPase (2) Reactive Oxygen Species (ROS) (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (4) Metabolic Disease (3) Neurological Disease (1)

Inhibitors & Agonists

Screening Libraries

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-116198

15-PGDH-IN-2	15-PGDH	Metabolic Disease
15-PGDH-IN-2 (Compound 2) is a 15-PGDH inhibitor with an IC₅₀ value of 0.274 nM. 15-PGDH-IN-2 can be used in research on hair loss, bone formation, gastric ulcer healing, and dermal wound healing .

HY-165498

AU-461	Na+/K+ ATPase	Metabolic Disease
AU-461 is an orally active and reversible inhibitor of the gastric H⁺/K⁺ ATPase with IC₅₀ values for rabbit-derived and pig-derived enzymes are 12.15 μM and 4.20 μM respectively. AU-461 competes with activated cationic K⁺ (Kᵢ = 1.64 μM). AU-461 reduces both histamine-stimulated gastric acid secretion and basal gastric acid secretion in rats. AU-461 inhibits ulcer formation caused by ethanol or sodium hydroxide, and restores the plasma gastrin level to normal. AU-461 can be used for the study of peptic ulcers .

HY-169833

BL 6341A	Histamine Receptor	Inflammation/Immunology
BL 6341A is an antagonist for histamine H2 receptor with K_i of 3.5-4.4 nM, that inhibits histamine-induced acid secretion and cAMP formation. BL 6341A can be used in research of gastric acid secretion related diseases, such as gastric ulcer or gastroesophageal reflux .

HY-170527

Anticancer agent 260	Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology Cancer
Anticancer agent 260 (Compound 3g/4d) is an orally active anticancer agent, that inhibits the proliferation of cancer cell HCT-116, MIA-PaCa2 and MDA-MB231 with IC₅₀s of 98.7, 81.0, and 77.2 µg/mL, respectively. Anticancer agent 260 exhibits promotes ulcer formation and lipid peroxidation, anti-inflammatory and analgesic efficacy .

HY-137962

Clanobutin	Drug Derivative	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Clanobutin is an orally active pharmaceutically acceptable N-acylanilinobutyric acid compound. Clanobutin increases gastrointestinal enzyme secretion. Clanobutin tonicizes the cardiovascular system, increases internal organ blood circulation, and boosts heart force. Clanobutin suppresses stomach ulcer formation and exhibits anti-hepatotoxic activity .

HY-W142456

(S)-1-Benzyl-5-carboxy-2-pyrrolidinone N-Benzyl-L-pyroglutamic acid	Na+/K+ ATPase	Inflammation/Immunology
(S)-1-Benzyl-5-carboxy-2-pyrrolidinone (N-Benzyl-L-pyroglutamic acid) is an orally active H ⁺/K ⁺-ATPase inhibitor. (S)-1-Benzyl-5-carboxy-2-pyrrolidinone reduces free acidity and total acidity in gastric juice. (S)-1-Benzyl-5-carboxy-2-pyrrolidinone decreases ulcer formation in pylorus-ligated rats. (S)-1-Benzyl-5-carboxy-2-pyrrolidinone can be used for the research of peptic ulcers .

HY-182310

Antibacterial agent 333	Bacterial	Infection
Antibacterial agent 333, Tryptanthrin (HY-N6607) derivative, is a antibacterial agent with antibacterial activity against Vibrio parahaemolyticus (MIC₅₀ = 8 μg/mL) and Vibrio alginolyticus (MIC₅₀ = 16 μg/mL). Antibacterial agent 333 inhibits biofilm formation and maturation. Antibacterial agent 333 exhibits activity against drug-resistant Vibrio strains. Antibacterial agent 333 lacks cytotoxicity toward mammalian cells and has no hemolytic activity. Antibacterial agent 333 can be used for the research of infection .

Cat. No.	Product Name

HY-L057

Phenols Library	1,290 compounds
Phenolic compounds are usually referred to as a diverse group of naturally occurring compounds with multiple medical properties, such as antioxidants, antimicrobial properties. Those compounds are commonly found in food and plants. They have high synthetic, medicinal and industrial values. Polyphenols are compounds with multiple phenolic functionalities. Naturally occurring polyphenols are known to have biological activities for use as drugs, for example, in diseases like AIDS, heart ailments, ulcer formation, bacterial infection, mutagenesis and neural disorders. MCE offers a unique collection of 1,290 natural phenol compounds which is a useful tool for drug discovery as an important source of lead compounds.

Phenols Library

1,290 compounds

Phenolic compounds are usually referred to as a diverse group of naturally occurring compounds with multiple medical properties, such as antioxidants, antimicrobial properties. Those compounds are commonly found in food and plants. They have high synthetic, medicinal and industrial values. Polyphenols are compounds with multiple phenolic functionalities. Naturally occurring polyphenols are known to have biological activities for use as drugs, for example, in diseases like AIDS, heart ailments, ulcer formation, bacterial infection, mutagenesis and neural disorders.

MCE offers a unique collection of 1,290 natural phenol compounds which is a useful tool for drug discovery as an important source of lead compounds.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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