2. Search Result
Search Result
Isoforms Recommended: αvβ6
Results for "

αvβ6

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

4

Peptides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P6010
    αvβ6-BP

    		Integrin Cancer
    αvβ6-BP is a selective αvβ6 binding peptide, and can be used for molecular imaging .
    αvβ6-BP
  • HY-P6010A
    αvβ6-BP TFA

    		Integrin Cancer
    αvβ6-BP TFA is a selective αvβ6 binding peptide, and can be used for research of molecular imaging .
    αvβ6-BP TFA
  • HY-153807
    αvβ6 integrin inhibitor 2

    		Integrin Inflammation/Immunology
    αvβ6 integrin inhibitor 2 is a potent ανβ6 integrin inhibitor with an IC50 of 96.5 nM (WO2020081154A1, example 19) .
    <em>αvβ6</em> integrin inhibitor 2
  • HY-P6009
    Cys-αvβ6-BP

    		Integrin Cancer
    Cys-αvβ6-BP is a cysteine-terminated αvβ6 binding peptide .
    Cys-αvβ6-BP
  • HY-P6009A
    Cys-αvβ6-BP TFA

    		Integrin Cancer
    Cys-αvβ6-BP TFA is a cysteine-terminated αvβ6 binding peptide .
    Cys-αvβ6-BP TFA
  • HY-137561
    Bexotegrast

    PLN-74809

    		 Integrin Inflammation/Immunology
    Bexotegrast (PLN-74809) is an orally active, potent dual αvβ6/αvβ1 integrin inhibitor with Kd of 5.7 nM and 3.4 nM, respectively. Bexotegrast inhibits αvβ6- and αvβ1-induced TGF-β activation with IC50 values of 29.8 nM and 19.2 nM, respectively. Bexotegrast has antifibrogenic effects and block multiple avenues of TGF-β activation in the fibrotic lung .
    Bexotegrast
  • HY-18644
    CWHM-12
    5 Publications Verification

    		 Integrin Cancer
    CWHM-12 is a potent inhibitor of αV integrins with IC50s of 0.2, 0.8, 1.5, and 1.8 nM for αvβ8, αvβ3, αvβ6, and αvβ1.
    CWHM-12
  • HY-101473
    EMD527040

    		Integrin Inflammation/Immunology
    EMD527040 is a potent and highly selective αvβ6 antagonist with antifibrotic activities. EMD527040 can be used for carcinoma and liver fibrosis research .
    EMD527040
  • HY-130119
    Integrin-IN-2

    		Integrin Cancer
    Integrin-IN-2 (compound 39) is an orally bioavailable pan αv integrin inhibitor. Integrin-IN-2 can increases the αvβ6, αvβ3, αvβ5 and αvβ8 binding affinities with pIC50 values of 7.8, 8.4, 8.4 and 7.4, respectively .
    Integrin-IN-2
  • HY-15102
    MK-0429
    3 Publications Verification

    L-000845704

    		 Integrin Inflammation/Immunology Cancer
    MK-0429 (L-000845704) is an orally active, potent, selective and nonpeptide pan-integrin antagonist with IC50 values of 1.6 nM, 2.8 nM, 0.1 nM, 0.7 nM, 0.5 nM and 12.2 nM for αvβ1, αvβ3, αvβ5, αvβ6, αvβ8 and α5β1, respectively .
    MK-0429
  • HY-117133
    Nesvategrast

    SF0166

    		 Integrin Metabolic Disease
    Nesvategrast (SF0166) is a potent and selective αvβ3 antagonist with IC50 values of 0.6 nM, 8 nM, and 13 nM for αvβ3, αvβ6, and αvβ8, respectively. Nesvategrast inhibits cellular adhesion to vitronectin across human, rat, rabbit, and dog cell lines with IC50 values of 7.6 pM to 76 nM. Nesvategrast decreases neovascularization in the oxygen-induced retinopathy mouse model .
    Nesvategrast
  • HY-19767A
    GSK 3008348 hydrochloride
    2 Publications Verification
    GSK 3008348 hydrochloride is a small molecule integrin αvβ6 antagonist, extracted from patent WO/2014154725A1, example 1. The affinity (pIC50) for the human - a 6 protein in the Fluorescence Polarisation Assay for GSK 3008348 (hydrochloride) is 8.1, whereas its affinity in the cell Adhesion Assays was for: ανβ6 (pIC50 = 8.4); ανβ3 (pIC50 = 6); ανβ5 (pIC50 = 6.9); ανβ8 (pIC50 = 7.7).
    GSK 3008348 hydrochloride

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: