1. Cytoskeleton
  2. Integrin

MK-0429 (Synonyms: L-000845704)

Cat. No.: HY-15102
Handling Instructions

MK-0429 is a potent integrin antagonist with IC50s of 12.2 nM (α5β1 integrin) and 2.8 nM (αvβ3 integrin), respectively.

For research use only. We do not sell to patients.

MK-0429 Chemical Structure

MK-0429 Chemical Structure

CAS No. : 227963-15-7

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

MK-0429 is a potent integrin antagonist with IC50s of 12.2 nM (α5β1 integrin) and 2.8 nM (αvβ3 integrin), respectively.

IC50 & Target

IC50: 12.2 nM (α5β1 integrin), 2.8 nM (αvβ3 integrin), 1.6 nM (αvβ1 integrin), 0.7 nM (αvβ6 integrin), 0.5 nM (αvβ8 integrin), 0.1 nM (αvβ5 integrin)[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2753 mL 11.3763 mL 22.7526 mL
5 mM 0.4551 mL 2.2753 mL 4.5505 mL
10 mM 0.2275 mL 1.1376 mL 2.2753 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

439.51

Formula

C₂₃H₂₉N₅O₄

CAS No.

227963-15-7

SMILES

O=C1N([[email protected]](C2=CC=C(OC)N=C2)CC(O)=O)CCN1CCCC3=NC4=C(C=C3)CCCN4

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
MK-0429
Cat. No.:
HY-15102
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MK-0429

Cat. No.: HY-15102