1. Cytoskeleton
  2. Integrin
  3. MK-0429

MK-0429 (Synonyms: L-000845704)

Cat. No.: HY-15102
Handling Instructions

MK-0429 (L-000845704) is an orally active, potent, selective and nonpeptide αvβ3 integrin antagonist with an IC50 of 80 nM.

For research use only. We do not sell to patients.

MK-0429 Chemical Structure

MK-0429 Chemical Structure

CAS No. : 227963-15-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 495 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3350 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

MK-0429 (L-000845704) is an orally active, potent, selective and nonpeptide αvβ3 integrin antagonist with an IC50 of 80 nM.

IC50 & Target

IC50: 80 nM (αvβ3 integrin)[1]

In Vivo

MK-0429 (100 or 300 mg/kg, p.o., twice daily b.i.d., 2 weeks) reduces metastatic tumor colony formation and area in the lungs. MK-0429 is safe and efficacious in significantly decreasing melanoma metastasis in the lungs[1].

Animal Model: B6D2F1 hybrid female mice[2]
Dosage: 100 or 300 mg/kg
Administration: P.o., twice daily (b.i.d.), 2 weeks
Result: MK-0429 at 100 and 300 mg/kg reduced the number of metastatic tumor colonies by 64 and 57%, respectively, and the high dose also reduced the tumor area by 60% as compared to the vehicle[2].
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (568.82 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2753 mL 11.3763 mL 22.7526 mL
5 mM 0.4551 mL 2.2753 mL 4.5505 mL
10 mM 0.2275 mL 1.1376 mL 2.2753 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.73 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.73 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.73 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

439.51

Formula

C₂₃H₂₉N₅O₄

CAS No.

227963-15-7

SMILES

O=C1N([[email protected]](C2=CC=C(OC)N=C2)CC(O)=O)CCN1CCCC3=NC4=C(C=C3)CCCN4

Shipping

Room temperature in continental US; may vary elsewhere

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MK-0429
Cat. No.:
HY-15102
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MK-0429

Cat. No.: HY-15102