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  2. Integrin
  3. Integrin-IN-2

Integrin-IN-2 

Cat. No.: HY-130119
Handling Instructions

Integrin-IN-2 (compound 39) is an orally bioavailable pan αv integrin inhibitor. Integrin-IN-2 can increases the αvβ6, αvβ3, αvβ5 and αvβ8 binding affinities with pIC50 values of 7.8, 8.4, 8.4 and 7.4, respectively.

For research use only. We do not sell to patients.

Integrin-IN-2 Chemical Structure

Integrin-IN-2 Chemical Structure

CAS No. : 2378617-67-3

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Description

Integrin-IN-2 (compound 39) is an orally bioavailable pan αv integrin inhibitor. Integrin-IN-2 can increases the αvβ6, αvβ3, αvβ5 and αvβ8 binding affinities with pIC50 values of 7.8, 8.4, 8.4 and 7.4, respectively[1].

IC50 & Target

pIC50: 7.8 (αvβ6), 8.4 (αvβ3), 8.4 (αvβ5) and 7.4 (αvβ8)[1]

In Vivo

In vivo pharmacokinetic studies in CD rats revealed that racemic Integrin-IN-2 (compound 39) has a low plasma clearance of 8 mL/(min kg), a low to moderate volume of distribution of 0.5 L/kg, a moderate halflife of 1.8 h, and very high bioavailability of 98%[1].

Molecular Weight

458.55

Formula

C₂₇H₃₀N₄O₃

CAS No.

2378617-67-3

SMILES

O=C(O)CC(C1=CC=CC(C2CC2)=C1)NC3=NC=C(OCCC4=NC5=C(CCCN5)C=C4)C=C3

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Integrin-IN-2IntegrinInhibitorinhibitorinhibit

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