2. GPCR/G Protein Neuronal Signaling
  3. Melanocortin Receptor
  4. Setmelanotide TFA

Setmelanotide TFA  (Synonyms: RM-493 TFA; BIM-22493 TFA; IRC-022493 TFA)

Cat. No.: HY-19870A
Handling Instructions Technical Support

Setmelanotide TFA (RM-493 TFA) is a selective melanocortin 4 receptor (MC4R) agonist with EC50s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Custom Peptide Synthesis

사이즈 재고
50 mg   견적 받기  
100 mg   견적 받기  
250 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Setmelanotide TFA:

Other Forms of Setmelanotide TFA:

Setmelanotide TFA Related Antibodies

Top Publications Citing Use of Products

    Setmelanotide TFA purchased from MedChemExpress. Usage Cited in: Sci Transl Med. 2025 Jan 15;17(781):eadr6459.  [Abstract]

    Setmelanotide (2 mg/kg; i.p.; once daily for 9 d) reduced body weights and food intake and improved glucose tolerance of HFD-fed OtpQ153R/+ mice, which quickly regained body weight after the treatment was discontinued.

    Setmelanotide TFA purchased from MedChemExpress. Usage Cited in: J Exp Med. 2021 Jul 5;218(7):e20202484.  [Abstract]

    Setmelanotide (100 nM) blocked the risperidone-induced hyperpolarization of MC4RPVH neurons.

    Setmelanotide TFA purchased from MedChemExpress. Usage Cited in: J Exp Med. 2021 Jul 5;218(7):e20202484.  [Abstract]

    A single dose of Setmelanotide (SET) (2 mg/kg; i.p.) suppressed fast-induced refeeding in Mc4rfl/fl mice.

    Setmelanotide TFA purchased from MedChemExpress. Usage Cited in: J Exp Med. 2021 Jul 5;218(7):e20202484.  [Abstract]

    Infusion of Setmelanotide (SET) (2 mg/kg; once daily for 14 d) attenuated hyperphagia in C57BL/6 mice fed with risperidone.

    Setmelanotide TFA purchased from MedChemExpress. Usage Cited in: J Exp Med. 2021 Jul 5;218(7):e20202484.  [Abstract]

    Setmelanotide (SET) (2 mg/kg; once daily for 14 d) caused accelerated glucose clearance of C57BL/6 mice fed with risperidone in a GTT.

    View All Melanocortin Receptor Isoform Specific Products:

    View All Isoforms
    MC1R MC3R MC2R MC4R MC5R

    • Biological Activity

    • 순도&문서

    • References

    • 고객리뷰

    제품 설명

    Setmelanotide TFA (RM-493 TFA) is a selective melanocortin 4 receptor (MC4R) agonist with EC50s of 0.27 nM and 0.28 nM for human and rat MC4R, respectively[1].

    IC50 & Target

    EC50: 5.8 nM (hMC1R), 5.3 nM (hMC3R), 0.27 nM (hMC4R), 0.28 nM (rMC4R), 1600 nM (hMC5R)[1]
    Ki:3.9 nM (hMC1R), 10 nM (hMC3R), 2.1 nM (hMC4R), 430 nM (hMC5R), 2.7 nM (rMC4R)[1]
    분자량

    1231.33

    화학식

    C51H69F3N18O11S2
    Sequence

    Ac-Arg-Cys-{d-Ala}-His-{d-Phe}-Arg-Trp-Cys-NH2 (Disulfide bridge:Cys2-Cys8)
    Sequence Shortening

    Ac-RC-{d-Ala}-H-{d-Phe}-RWC-NH2 (Disulfide bridge:Cys2-Cys8)
    선적

    Room temperature in continental US; may vary elsewhere.
    보관

    Please store the product under the recommended conditions in the Certificate of Analysis.
    순도&문서
    References
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Setmelanotide TFA Related Classifications

    • 몰농도 계산기

    • 농도 희석 계산기

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    SetmelanotideRM-493BIM-22493IRC-022493RM493RM 493BIM22493BIM 22493IRC022493IRC 022493Melanocortin ReceptorMC ReceptorInhibitorinhibitorinhibit

    최근 본 상품:

    온라인 문의

    Your information is safe with us. * Required Fields.

    상품명

    		  

    Requested Quantity *

    고객명 *

    		 

    호칭

    메일주소 *

    		 

    전화번호 *

    Department

    		 

    회사명 *

    City

    도

    Country or Region *

    		      

    비고

    대량구매 문의

    Inquiry Information

    상품명:
    Setmelanotide TFA
    Cat. No.:
    HY-19870A
    수량:
    MCE Japan Authorized Agent:

    고객리뷰

    Thank You for Your Feedback!

    Request for HNMR Report

    Please fill out this form to request the QC report. We will send it to your Email address shortly.

    Your information is safe with us. * Required Fields.

    상품명

    		  

    Lot #

    고객명 *

    		 

    메일주소 *

    전화번호

    		 

    Department *

    회사명 *

    		 

    Country or Region *

    비고

    SAFETY DATA SHEET (SDS)

    Request for HNMR Report

    We have received your request and will respond to you as soon as possible.