SK3 Channel-IN-1

製品番号: HY-147556: Data Sheet 取扱説明書
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SK3 Channel-IN-1 (compound 7a) is a potent and specific SK3 channel modulator. SK3 Channel-IN-1 has efficient effect on breast cancer MDA-MB-435 cell migration while exhibiting low cytotoxicity in other cell lines. SK3 Channel-IN-1 can modulate ion channels’activity in cancer.

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SK3 Channel-IN-1 構造式

CAS 番号 : 2396571-04-1

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生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target

IC₅₀: 16 μM in CaCo-2^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	IC₅₀	16 3 Compound: 7a	Toxicity in human Caco-2 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay Toxicity in human Caco-2 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay	[PMID: 31753515]
Caco-2	IC₅₀	16 3 Compound: 7a	Toxicity in human Caco-2 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay Toxicity in human Caco-2 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay	[PMID: 31753515]
Caco-2	IC₅₀	16 3 Compound: 7a	Toxicity in human Caco-2 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay Toxicity in human Caco-2 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay	[PMID: 31753515]
Fibroblast	IC₅₀	> 25 3 Compound: 7a	Toxicity in human skin fibroblasts assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay Toxicity in human skin fibroblasts assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay	[PMID: 31753515]
Fibroblast	IC₅₀	>25 3 Compound: 7a	Toxicity in human skin fibroblasts assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay Toxicity in human skin fibroblasts assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay	[PMID: 31753515]
Fibroblast	IC₅₀	> 25 3 Compound: 7a	Toxicity in human skin fibroblasts assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay Toxicity in human skin fibroblasts assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay	[PMID: 31753515]
HCT-116	IC₅₀	> 25 3 Compound: 7a	Toxicity in human HCT-116 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay Toxicity in human HCT-116 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay	[PMID: 31753515]
HCT-116	IC₅₀	>25 3 Compound: 7a	Toxicity in human HCT-116 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay Toxicity in human HCT-116 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay	[PMID: 31753515]
HCT-116	IC₅₀	> 25 3 Compound: 7a	Toxicity in human HCT-116 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay Toxicity in human HCT-116 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay	[PMID: 31753515]
Huh-7	IC₅₀	> 25 3 Compound: 7a	Toxicity in human Huh-7 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay Toxicity in human Huh-7 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay	[PMID: 31753515]
Huh-7	IC₅₀	>25 3 Compound: 7a	Toxicity in human Huh-7 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay Toxicity in human Huh-7 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay	[PMID: 31753515]
Huh-7	IC₅₀	> 25 3 Compound: 7a	Toxicity in human Huh-7 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay Toxicity in human Huh-7 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay	[PMID: 31753515]
MCF7	IC₅₀	> 25 3 Compound: 7a	Toxicity in human MCF7 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay Toxicity in human MCF7 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay	[PMID: 31753515]
MCF7	IC₅₀	> 25 3 Compound: 7a	Toxicity in human MCF7 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay Toxicity in human MCF7 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay	[PMID: 31753515]
MCF7	IC₅₀	>25 3 Compound: 7a	Toxicity in human MCF7 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay Toxicity in human MCF7 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay	[PMID: 31753515]
MDA-MB-231	IC₅₀	>25 3 Compound: 7a	Toxicity in human MDA-MB-231 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay Toxicity in human MDA-MB-231 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay	[PMID: 31753515]
MDA-MB-231	IC₅₀	> 25 3 Compound: 7a	Toxicity in human MDA-MB-231 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay Toxicity in human MDA-MB-231 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay	[PMID: 31753515]
MDA-MB-231	IC₅₀	> 25 3 Compound: 7a	Toxicity in human MDA-MB-231 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay Toxicity in human MDA-MB-231 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay	[PMID: 31753515]
NCI-H727	IC₅₀	>25 3 Compound: 7a	Toxicity in human NCI-H727 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay Toxicity in human NCI-H727 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay	[PMID: 31753515]
NCI-H727	IC₅₀	> 25 3 Compound: 7a	Toxicity in human NCI-H727 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay Toxicity in human NCI-H727 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay	[PMID: 31753515]
PC-3	IC₅₀	> 25 3 Compound: 7a	Toxicity in human PC-3 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay Toxicity in human PC-3 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay	[PMID: 31753515]
PC-3	IC₅₀	>25 3 Compound: 7a	Toxicity in human PC-3 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay Toxicity in human PC-3 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay	[PMID: 31753515]
NCI-H727	IC₅₀	> 25 3 Compound: 7a	Toxicity in human NCI-H727 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay Toxicity in human NCI-H727 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay	[PMID: 31753515]
PC-3	IC₅₀	> 25 3 Compound: 7a	Toxicity in human PC-3 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay Toxicity in human PC-3 cells assessed as reduction in cell number after 48 hrs by Hoechst 33342 staining based assay	[PMID: 31753515]

分子量

379.66

分子式

C₂₅H₄₉NO

CAS 番号

2396571-04-1

SMILES

CCCCCCCCCCCCCCCCC[C@@H](C[C@@H]1C=CCCN1C)O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Kouba S, et al. Lipidic synthetic alkaloids as SK3 channel modulators. Synthesis and biological evaluation of 2-substituted tetrahydropyridine derivatives with potential anti-metastatic activity. Eur J Med Chem. 2020;186:111854. [Content Brief]

SK3 Channel-IN-1 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SK3 Channel-IN-12396571-04-1Potassium ChannelKcsABreast cancerCell migrationIon channelAnticancerMDA-MB-435?cellsInhibitorinhibitorinhibit

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