Sodium zirconium cyclosilicate 

Sodium zirconium cyclosilicate is an orally administered, non-absorbed, novel, inorganic microporous zirconium silicate compound, is a highly selective cation exchanger that selectively removes excess K⁺ in vivo. Sodium zirconium cyclosilicate can be used in research of chronic kidney disease (CKD)^[1][2].

Sodium zirconium cyclosilicate (ZS-9) is an inorganic cation exchange crystalline compound that has a high capacity to selectively entrap monovalent cations, specifically excess K⁺ and ammonium ions. Sodium zirconium cyclosilicate has the exchange capacities for the divalent ions Ca²⁺ and Mg²⁺ are below 0.05 mEq/g, and a >25-fold selectivity for K⁺ over either Ca²⁺ or Mg^2+[1]. Dissolution Precautions: Sodium zirconium cyclosilicate can be prepared as a 1 mg/mL suspension in water as a stock solution, aliquoted, and stored at -80°C. This product is essentially an insoluble inorganic crystal that exists as a solid in the gastrointestinal tract, adsorbing potassium ions (K⁺) through an ion exchange mechanism rather than through dissolution.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sodium zirconium cyclosilicate (ZS-9; 2-6 g/kg; p.o.; daily, for 5 d) is a recovery in feces of Sprague-Dawley rats and can efficient uptake and removal of potassium ions^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

371.50

H₆O₉Si₃.2Na.Zr

17141-74-1

Solid

White to off-white

O[Si]1(O[Si](O)(O[Si](O)(O)O1)O)O.[Na].[Zr].[Na]

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Stavros F, et, al. Characterization of structure and function of ZS-9, a K+ selective ion trap. PLoS One. 2014 Dec 22;9(12):e114686.  [Content Brief]

  [2]. Ash SR, et, al. A phase 2 study on the treatment of hyperkalemia in patients with chronic kidney disease suggests that the selective potassium trap, ZS-9, is safe and efficient. Kidney Int. 2015 Aug;88(2):404-11.  [Content Brief]