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  4. Sorbitan trioleate

Sorbitan trioleate (Span 85) is an orally active non-ionic surface active agent. Sorbitan trioleate can be used as an excipient, such as surfactant, emulsifier, lubricant, wetting agent, dispersant, thickener, defoamer.

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Sorbitan trioleate

Sorbitan trioleate Chemical Structure

CAS No. : 26266-58-0

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Sorbitan trioleate Related Antibodies

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Description

Sorbitan trioleate (Span 85) is an orally active non-ionic surface active agent. Sorbitan trioleate can be used as an excipient, such as surfactant, emulsifier, lubricant, wetting agent, dispersant, thickener, defoamer[1][2][3].

In Vitro

Pharmaceutical excipients, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2][3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sorbitan trioleate Related Antibodies
In Vivo

Sorbitan trioleate (12.5-200.0 mg/kg; i.v.; daily; 35 days) shows no toxic effects at doses up to 50.0 mg/kg in Wistar rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (5-week-old)[2]
Dosage: 12.5; 50.0; 200.0 mg/kg
Administration: i.v.; daily; 35 days
Result: Showed no abnormalities in general symptoms, body weight gain, or food/water consumption compared to controls at all doses.
Observed only a significant decrease in Na and Cl levels in males at 12.5 mg/kg.
Found any statistically significant changes in hematological, serum biochemical, or organ weight parameters fell within normal ranges at 12.5 mg/kg and 50.0 mg/kg.
Showed no meaningful gross or histological tissue changes beyond minor, non-toxic effects at 12.5 mg/kg and 50.0 mg/kg.
Induced significant decreases in red blood cell count, hemoglobin, and hematocrit, alongside significant increases in prothrombin time and reticulocyte count, indicating mild anemia at 200.0 mg/kg.
Caused significant increase in total cholesterol; significant decreases in male alkaline phosphatase, blood urea nitrogen, albumin, A/G ratio, sodium, chloride, and creatinine; significant decreases in female glutamic-oxaloacetic transaminase, glutamic-pyruvic transaminase, albumin, A/G ratio, sodium, chloride, and creatinine at 200.0 mg/kg.
CAS No.
Appearance

Liquid (Density: 0.94 g/cm3)

Color

Colorless to light yellow

SMILES

CCCCCCCC/C=C\CCCCCCCC(OC[C@@H](O)[C@@H]1[C@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)[C@@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)CO1)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvant et solubilité
In Vitro: 

DMSO : 200 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Pureté et documentation

SDS (393 KB)

COA (239 KB) MS (303 KB)

Instruction de manipulation (2659 KB)
Références
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Sorbitan trioleate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sorbitan trioleate26266-58-0Span 85Span85Span-85Environmental PollutantsBiochemical Assay ReagentsEnvironmental Contaminantspirenzepine dihydrochloridespleenDMBAoleic acidWistar ratsbone marrowsorbitolcocoa butterrabbit skinmouse skinInhibitorinhibitorinhibit

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