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Sorbitan trioleate (Span 85) is an orally active non-ionic surface active agent. Sorbitan trioleate can be used as an excipient, such as surfactant, emulsifier, lubricant, wetting agent, dispersant, thickener, defoamer.

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Sorbitan trioleate

Sorbitan trioleate 構造式

CAS 番号 : 26266-58-0

容量 価格(税別) 在庫状況 数量
500 g $35 在庫あり
1 kg $65 在庫あり
2.5 kg $130 在庫あり

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製品説明

Sorbitan trioleate (Span 85) is an orally active non-ionic surface active agent. Sorbitan trioleate can be used as an excipient, such as surfactant, emulsifier, lubricant, wetting agent, dispersant, thickener, defoamer[1][2][3].

体外実験

Pharmaceutical excipients, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2][3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Sorbitan trioleate (12.5-200.0 mg/kg; i.v.; daily; 35 days) shows no toxic effects at doses up to 50.0 mg/kg in Wistar rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (5-week-old)[2]
Dosage: 12.5; 50.0; 200.0 mg/kg
Administration: i.v.; daily; 35 days
Result: Showed no abnormalities in general symptoms, body weight gain, or food/water consumption compared to controls at all doses.
Observed only a significant decrease in Na and Cl levels in males at 12.5 mg/kg.
Found any statistically significant changes in hematological, serum biochemical, or organ weight parameters fell within normal ranges at 12.5 mg/kg and 50.0 mg/kg.
Showed no meaningful gross or histological tissue changes beyond minor, non-toxic effects at 12.5 mg/kg and 50.0 mg/kg.
Induced significant decreases in red blood cell count, hemoglobin, and hematocrit, alongside significant increases in prothrombin time and reticulocyte count, indicating mild anemia at 200.0 mg/kg.
Caused significant increase in total cholesterol; significant decreases in male alkaline phosphatase, blood urea nitrogen, albumin, A/G ratio, sodium, chloride, and creatinine; significant decreases in female glutamic-oxaloacetic transaminase, glutamic-pyruvic transaminase, albumin, A/G ratio, sodium, chloride, and creatinine at 200.0 mg/kg.

CAS 番号
Appearance

Liquid (Density: 0.94 g/cm3)

Color

Colorless to light yellow

SMILES

CCCCCCCC/C=C\CCCCCCCC(OC[C@@H](O)[C@@H]1[C@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)[C@@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)CO1)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 200 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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製品名:
Sorbitan trioleate
製品番号:
HY-W115716
数量:
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