2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. SS28

SS28, a SRT501 analog with oral bioavailability, inhibits tubulin polymerization to cause cell cycle arrest at G2/M phase. SS28 results in apoptosis rather than necrosis tubulin.

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SS28

SS28 構造式

CAS 番号 : 141172-08-9

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SS28 関連抗体

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製品説明

SS28, a SRT501 analog with oral bioavailability, inhibits tubulin polymerization to cause cell cycle arrest at G2/M phase. SS28 results in apoptosis rather than necrosis tubulin[1].

IC50 & Target

Tubulin[1].
Cellular Effect
Cell Line Type Value Description References
A549 ED50
9.4 μM
Compound: 6d
Compound was evaluated for cytotoxicity against human A-549 non-small cell lung cancer cell line.
Compound was evaluated for cytotoxicity against human A-549 non-small cell lung cancer cell line.
[PMID: 1613753]
HT-29 ED50
2.3 μM
Compound: 6d
Cytotoxicity against human HT-29 colon cell line.
Cytotoxicity against human HT-29 colon cell line.
[PMID: 1613753]
MCF7 ED50
2.4 μM
Compound: 6d
Cytotoxicity against human MCF-7 breast cancer cell line.
Cytotoxicity against human MCF-7 breast cancer cell line.
[PMID: 1613753]
MLM ED50
6.6 μM
Compound: 6d
Cytotoxicity against human MLM melanoma cell line.
Cytotoxicity against human MLM melanoma cell line.
[PMID: 1613753]
SK-MEL-5 ED50
8.3 μM
Compound: 6d
Compound was evaluated for cytotoxicity against human SKMEL-5 melanoma cell line.
Compound was evaluated for cytotoxicity against human SKMEL-5 melanoma cell line.
[PMID: 1613753]
体外実験

SS28 (0-20 μM) induces cytotoxicity in different cancer cell lines[1].
SS28 treatment (5 μM for A549 and 2 μM for CEM) results in cell cycle arrest at G2/M phase leading to apoptosis upon further incubation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SS28 関連抗体

Cell Proliferation Assay[1]

Cell Line: CEM, Reh, Nalm6, SUDHL8, Molt4, A549, HeLa 293T cells.
Concentration: 1, 5, 10 and 20 μM.
Incubation Time: 48 and 72 h.
Result: CEM and A549 exhibited maximum sensitivity to SS28 followed by SUDHL8, Molt4 and Reh, whereas Nalm6 showed moderate sensitivity after 48 h of the treatment. IC50 values of SS28 in CEM and A549 cell line were 2.6 and 5.2 μM, respectively, whereas in SUDHL8, Molt4, Reh and Nalm6 were 2.7, 5.1, 7.9 and 21 μ M, respectively after 48 h of treatment.

Cell Cycle Analysis[1]

Cell Line: CEM and A549 cells.
Concentration: 2 μM (CEM) and 5 μM (A549).
Incubation Time: 6, 12, 18, 24 and 30 h.
Result: Showed significant accumulation of cells at G2/M phase in a time-dependent manner (6 to 24 h) and a subsequent increase in the sub-G1 population, indicative of apoptosis at 30 h in case of A549. Similarly, studies in CEM also showed a distinct G2/M arrest after 12 h of treatment, as compared to vehicle control.
体内実験

SS28 (15 mg/kg. b.wt.) treatment results in inhibition of tumor cell proliferation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice using EAC cells[1].
Dosage: 15 mg/kg.
Administration: Orally on every alternate day for 9 doses.
Result: There was no further tumor progression in the mice when SS28 was administered, unlike the untreated tumor control mice.
分子量

284.35

分子式

C18H20O3
CAS 番号
SMILES

CC1=CC=C(/C=C\C2=CC(OC)=C(OC)C(OC)=C2)C=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
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SS28 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SS28141172-08-9SS 28SS-28Microtubule/TubulinApoptosisInhibitorinhibitorinhibit

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